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This version published online on April 20, 2006
Endocrinology, doi:10.1210/en.2005-1007
A more recent version of this article appeared on July 1, 2006
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Submitted on August 8, 2005
Accepted on April 7, 2006

Taurine deficiency creates a vicious circle promoting obesity

Nobuyo Tsuboyama-Kasaoka*, Chikako Shozawa, Kayo Sano, Yasutomi Kamei, Seiichi Kasaoka, Yu Hosokawa, and Osamu Ezaki

Division of Clinical Nutrition, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan; Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Department of Health and Nutrition, Bunkyo University Women's College, Kanagawa, Japan; Department of Food and Health Science, Jissen Women's University, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: ntsubo{at}nih.go.jp.

The relation between blood taurine concentrations and obesity was investigated. Taurine is supplied to the body by dietary ingestion as well as by de novo synthesis; it is catabolized by cysteine dioxygenase (CDO), which is abundantly expressed in liver and white adipose tissue (WAT). Overexpression of CDO in 3T3-L1 preadipocytes caused a decrease in the level of cysteine (precursor of taurine) and an increase in the level of taurine in the culture medium, suggesting that CDO is involved in biosynthesis and secretion of taurine in WAT. In high-fat diet-induced and/or genetically obese mice, a decrease in the blood taurine concentration was observed along with a decrease in CDO expression in adipose tissue but not in liver. Dietary taurine supplementation prevented high-fat diet-induced obesity with increased resting energy expenditure. Thus, taurine deficiency observed in association with obesity may create a vicious circle promoting obesity. Dietary taurine supplementation interrupts this vicious circle and may prevent obesity.
Key words: obesity • CDO • taurine • adipocytes • visceral fat






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