| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 27, 2005
Accepted on June 13, 2005
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan; Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka 565-8565, Japan; Laboratory of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo 113-8657, Japan
* To whom correspondence should be addressed. E-mail: a0d201u{at}cc.miyazaki-u.ac.jp.
A novel 36-amino acid neuropeptide, neuromedin S (NMS), has recently been identified in rat brain and has been shown to be an endogenous ligand for two orphan G protein-coupled receptors, FM-3/GPR66 and FM-4/TGR-1. These receptors have been identified as neuromedin U (NMU) receptor type-1 and type-2, respectively. In this study, the physiological role of the novel peptide, NMS, on feeding regulation was investigated. Intracerebroventricular (icv) injection of NMS decreased 12-h food intake during the dark period in rats. This anorexigenic effect was more potent and persistent than that observed with the same dose of NMU. Neuropeptide Y, ghrelin and agouti-related protein-induced food intake was counteracted by co-administration of NMS. Icv administration of NMS increased proopiomelanocortin (POMC) mRNA expression in the arcuate nucleus (Arc) and CRH (CRH) mRNA in the paraventricular nucleus (PVN). Pretreatment with SHU9119 (antagonist for 
-melanocyte-stimulating hormone) and -helical CRF- (9-41) (antagonist for CRH) attenuated NMS-induced suppression of 24 h food intake. After icv injection of NMS, Fos-immunoreactive cells were detected in both the PVN and Arc. When neuronal multiple unit activity was recorded in the PVN before and after icv injection of NMS, a significant increase in firing rate was observed 5 min after administration, and this increase continued for 100 min.
These results suggest that the novel peptide, NMS, may be a potent anorexigenic hormone in the hypothalamus, and that expression of POMC mRNA in the Arc and CRH mRNA in the PVN may be involved in NMS action on feeding.
This article has been cited by other articles:
 |
|
 |
|
  E. Vigo, J. Roa, R. Pineda, J. M. Castellano, V. M. Navarro, E. Aguilar, L. Pinilla, and M. Tena-Sempere Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1265 - E1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Melcher, R. Bader, and M. J Pankratz Amino acids, taste circuits, and feeding behavior in Drosophila: towards understanding the psychology of feeding in flies and man J. Endocrinol., March 1, 2007; 192(3): 467 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Vigo, J. Roa, M. Lopez, J. M. Castellano, R. Fernandez-Fernandez, V. M. Navarro, R. Pineda, E. Aguilar, C. Dieguez, L. Pinilla, et al. Neuromedin S as Novel Putative Regulator of Luteinizing Hormone Secretion Endocrinology, February 1, 2007; 148(2): 813 - 823. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
