help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on January 27, 2005
Endocrinology, doi:10.1210/en.2004-1572
A more recent version of this article appeared on May 1, 2005
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
146/5/2157    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sennello, J. A.
Right arrow Articles by Fantuzzi, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sennello, J. A.
Right arrow Articles by Fantuzzi, G.

Submitted on December 3, 2004
Accepted on January 21, 2005

Regulation of T-cell mediated hepatic inflammation by adiponectin and leptin

Joseph A. Sennello, Raja Fayad, Alison M. Morris, Robert H. Eckel, Esra Asilmaz, Jason Montez, Jeffrey M. Friedman, Charles A. Dinarello, and Giamila Fantuzzi*

Division of Infectious Diseases and Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, CO; Rockefeller University, New York, NY, Howard Hughes Medical Institute

* To whom correspondence should be addressed. E-mail: giamila{at}uic.edu.

ConA-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob/ob mice and lean wild-type (WT) mice. Serum leptin and adiponectin were low in LD mice, whereas ob/ob mice had undetectable leptin but high adiponectin. Protection from hepatotoxicity was observed in ob/ob, but not in LD mice, despite low cytokine levels and reduced T cell activation and hepatic NK T cells in both groups. Administration of adiponectin protected LD mice from hepatotoxicity without altering cytokine levels. In contrast, administration of leptin heightened disease susceptibility by restoring cytokine production. Neutralization of TNF{alpha} protected LD mice from liver damage. Increased in vivo susceptibility to the hepatotoxic effect of TNF{alpha} was observed in LD mice. In vitro, adiponectin protected primary hepatocytes from TNF{alpha}-induced death, whereas leptin had no protective effect. In conclusion, whereas leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF{alpha}-induced death.
Key words: tumor necrosis factor • adipose tissue • inflammation • cytokines • lymphocytes




This article has been cited by other articles:


Home page
 EndocrinologyHome page
M. Pini, M. E. Gove, J. A. Sennello, J. W. P. M. van Baal, L. Chan, and G. Fantuzzi
Role and Regulation of Adipokines during Zymosan-Induced Peritoneal Inflammation in Mice
Endocrinology, August 1, 2008; 149(8): 4080 - 4085.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
N. Stefanou, M. Satra, V. Papanikolaou, F. Kalala, N. Gatselis, A. Germenis, G. N. Dalekos, and A. Tsezou
Leptin receptor isoforms mRNA expression in peripheral blood mononuclear cells from patients with chronic viral hepatitis.
Experimental Biology and Medicine, November 1, 2006; 231(10): 1653 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Pini, J. A. Sennello, L. Chan, and G. Fantuzzi
Adiponectin Deficiency Does Not Affect the Inflammatory Response to Endotoxin or Concanavalin A in Mice
Endocrinology, November 1, 2006; 147(11): 5019 - 5022.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
H. Laivuori, M.J. Gallaher, L. Collura, W.R. Crombleholme, N. Markovic, A. Rajakumar, C.A. Hubel, J.M. Roberts, and R.W. Powers
Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia
Mol. Hum. Reprod., September 1, 2006; 12(9): 551 - 556.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K.-y. Kim, J. K. Kim, S. H. Han, J.-S. Lim, K. I. Kim, D. H. Cho, M.-S. Lee, J.-H. Lee, D.-Y. Yoon, S. R. Yoon, et al.
Adiponectin Is a Negative Regulator of NK Cell Cytotoxicity
J. Immunol., May 15, 2006; 176(10): 5958 - 5964.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C.-H. Lee, Y.-G. Chen, J. Chen, P. C. Reifsnyder, D. V. Serreze, M. Clare-Salzler, M. Rodriguez, C. Wasserfall, M. A. Atkinson, and E. H. Leiter
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Diabetes, January 1, 2006; 55(1): 171 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. W. Wieland, S. Florquin, E. D. Chan, J. C. Leemans, S. Weijer, A. Verbon, G. Fantuzzi, and T. van der Poll
Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
Int. Immunol., November 1, 2005; 17(11): 1399 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
L. A. Adams, P. Angulo, and K. D. Lindor
Nonalcoholic fatty liver disease
Can. Med. Assoc. J., September 27, 2005; 173(7): 735 - 735.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
J. P. McGillis
White Adipose Tissue, Inert No More!
Endocrinology, May 1, 2005; 146(5): 2154 - 2156.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society