| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on October 15, 2003
Accepted on December 2, 2003
1 Luis M. Garcia-Segura, Ph.D, Instituto Cajal, C.S.I.C., 28002 Madrid, Spain; Margaret M. McCarthy, Ph.D, Department of Physiology and Program in Neuroscience, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201, USA
Long relegated to the backwaters of neuroendocrinology, it is becoming increasingly apparent that glial cells of the central and peripheral nervous system are key participants as they are capable of both sending and receiving hormonal signals. Hormones are also a critical component of neuronal/glial crosstalk, leading to neuromodulatory and neurotrophic actions under physiological and pathological conditions. In the peripheral nervous system, hormonal actions on Schwann cells, and hormonal metabolites produced by these glial cells, promote myelin formation and the remyelination and regeneration of injured nerves. In the central nervous system, glial cells participate in the hormonal regulation of synaptic function, synaptic plasticity, myelin formation, cognition, sleep, and the response of nervous tissue to injury. In addition, central glial cells participate in the regulation of hormonal secretion by hypothalamic neurons. Therefore, glial cells are a key element to understanding hormonal actions in the nervous system and the regulation of neuroendocrine events.
This article has been cited by other articles:
 |
|
 |
|
  D. T. Theodosis, D. A. Poulain, and S. H. R. Oliet Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions Physiol Rev, July 1, 2008; 88(3): 983 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Caruso, D. Durand, H. B. Schioth, R. Rey, A. Seilicovich, and M. Lasaga Activation of Melanocortin 4 Receptors Reduces the Inflammatory Response and Prevents Apoptosis Induced by Lipopolysaccharide and Interferon-{gamma} in Astrocytes Endocrinology, October 1, 2007; 148(10): 4918 - 4926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schumacher, R. Guennoun, A. Ghoumari, C. Massaad, F. Robert, M. El-Etr, Y. Akwa, K. Rajkowski, and E.-E. Baulieu Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System Endocr. Rev., June 1, 2007; 28(4): 387 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Glidewell-Kenney, L. A. Hurley, L. Pfaff, J. Weiss, J. E. Levine, and J. L. Jameson Nonclassical estrogen receptor {alpha} signaling mediates negative feedback in the female mouse reproductive axis PNAS, May 8, 2007; 104(19): 8173 - 8177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Naftolin, L. M. Garcia-Segura, T. L. Horvath, A. Zsarnovszky, N. Demir, A. Fadiel, C. Leranth, S. Vondracek-Klepper, C. Lewis, A. Chang, et al. Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge Reproductive Sciences, February 1, 2007; 14(2): 101 - 116. [Abstract] [PDF]
|
|
|
|
|
|
A. M. Lechuga-Sancho, A. I. Arroba, L. M. Frago, C. Garcia-Caceres, A. D.-R. de Celix, J. Argente, and J. A. Chowen Reduction in the Number of Astrocytes and Their Projections Is Associated with Increased Synaptic Protein Density in the Hypothalamus of Poorly Controlled Diabetic Rats Endocrinology, November 1, 2006; 147(11): 5314 - 5324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Turgeon, M. C. Carr, P. M. Maki, M. E. Mendelsohn, and P. M. Wise Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies Endocr. Rev., October 1, 2006; 27(6): 575 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Dubal, S. W. Rau, P. J. Shughrue, H. Zhu, J. Yu, A. B. Cashion, S. Suzuki, L. M. Gerhold, M. B. Bottner, S. B. Dubal, et al. Differential Modulation of Estrogen Receptors (ERs) in Ischemic Brain Injury: A Role for ER{alpha} in Estradiol-Mediated Protection against Delayed Cell Death Endocrinology, June 1, 2006; 147(6): 3076 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Gerhold and P. M. Wise Vasoactive Intestinal Polypeptide Regulates Dynamic Changes in Astrocyte Morphometry: Impact on Gonadotropin-Releasing Hormone Neurons Endocrinology, May 1, 2006; 147(5): 2197 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Ojeda, A. Lomniczi, C. Mastronardi, S. Heger, C. Roth, A.-S. Parent, V. Matagne, and A. E. Mungenast Minireview: The Neuroendocrine Regulation of Puberty: Is the Time Ripe for a Systems Biology Approach? Endocrinology, March 1, 2006; 147(3): 1166 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamamura, K. Hirunagi, S. Ebihara, and T. Yoshimura Seasonal Morphological Changes in the Neuro-Glial Interaction between Gonadotropin-Releasing Hormone Nerve Terminals and Glial Endfeet in Japanese Quail Endocrinology, September 1, 2004; 145(9): 4264 - 4267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Blaustein Can You Teach an Old Dogma New Tricks? Endocrinology, March 1, 2004; 145(3): 1055 - 1056. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
