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This version published online on August 7, 2003
Endocrinology, doi:10.1210/en.2003-0536
A more recent version of this article appeared on November 1, 2003
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Submitted on April 28, 2003
Accepted on August 1, 2003

A Role for Neuropeptide W in the Regulation of Feeding Behavior

MUHTASHAN S. MONDAL1, HIDEKI YAMAGUCHI1, YUKARI DATE1, TAKUYA SHIMBARA1, KOJI TOSHINAI1, YUKIO SHIMOMURA1, MASAAKI MORI1, and MASAMITSU NAKAZATO1*

1 Department of Internal Medicine (M.S.M., H.Y., Y.D., T.S., K.T., M.N.), Miyazaki Medical College, Miyazaki 889-1692, Japan; Discovery Research Laboratories (Y.S., M.M.), Pharmaceuticals Research Division, Takeda Chemical Industries Limited, Ibaraki 300-4293, Japan

* To whom correspondence should be addressed. E-mail: nakazato{at}post.miyazaki-med.ac.jp.

Neuropeptide W (NPW) is a novel hypothalamic peptide which activates the previously described orphan G protein-coupled receptors, GPR7 and GPR8. Two endogenous molecular forms of NPW that consist of 23 and 30 amino acid residues were identified. The localization of GPR7 and GPR8 in some hypothalamic regions of primary importance in the regulation of feeding behavior has provided a springboard for investigation into the role of NPW in the central nervous system. In this study, we examined the effects of NPW on feeding and energy expenditure in rats. Single intracerebroventricular (icv) administration of NPW23 and NPW30 given to free-feeding rats suppressed dark-phase and fasting-induced food intake at similar effective doses. Continuous icv infusion of NPW using an osmotic minipump suppressed feeding and body weight gain over the infusion period. Conversely, icv administration of anti-NPW IgG stimulated feeding. Furthermore, icv administration of NPW increased body temperature and heat production. These data raise the possibility that NPW functions as an endogenous catabolic signaling molecule in the brain. Further investigation of the biochemical and physiological functions of NPW will help us to better understand the hypothalamic regulation of energy homeostasis.
Key words: Neuropeptide W • GPR7 • central administration • anorectic activity • energy expenditure




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