help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miyazaki, J.
Right arrow Articles by Yamamura, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyazaki, J.
Right arrow Articles by Yamamura, K.

Endocrinology, Vol 127, 126-132, Copyright © 1990 by Endocrine Society

ARTICLES

Establishment of a pancreatic beta cell line that retains glucose- inducible insulin secretion: special reference to expression of glucose transporter isoforms

J Miyazaki, K Araki, E Yamato, H Ikegami, T Asano, Y Shibasaki, Y Oka and K Yamamura
Institute for Medical Genetics, Kumamoto University Medical School, Japan.

Two cell lines have been established from insulinomas obtained by targeted expression of the simian virus 40 T antigen gene in transgenic mice. These cell lines, designated MIN6 and MIN7, produce insulin and T antigen and have morphological characteristics of pancreatic beta cells. MIN6 cells exhibit glucose-inducible insulin secretion comparable with cultured normal mouse islet cells, whereas MIN7 cells do not. Both cell lines produce liver-type glucose transporter (GT) mRNA at high level. Brain-type GT mRNA is also present at considerable level in MIN7 cells, but is barely detectable in MIN6 cells, suggesting that exclusive expression of the liver-type GT is related to glucose- inducible insulin secretion. MIN6 cells do not express either major histocompatibility (MHC) class I or class II antigens on the cell surface. However, treatment with interferon-gamma induces high levels of MHC class I antigens, and a combination of interferon-gamma and tumor necrosis factor-alpha induces a MHC class II antigen on the cell surface. These results emphasize that the MIN6 cell line retains physiological characteristics of normal beta cells. The MIN6 cell line will be especially useful to analyze the molecular mechanisms by which beta cells regulate insulin secretion in response to extracellular glucose concentrations. We discuss a possible role of GT isoforms in glucose sensing by beta cells.


This article has been cited by other articles:


Home page
 DiabetesHome page
I. Cozar-Castellano, G. Harb, K. Selk, K. Takane, R. Vasavada, B. Sicari, B. Law, P. Zhang, D. K. Scott, N. Fiaschi-Taesch, et al.
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
Diabetes, November 1, 2008; 57(11): 3056 - 3068.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J.-C. Chuang, J.-Y. Cha, J. C. Garmey, R. G. Mirmira, and J. J. Repa
Research Resource: Nuclear Hormone Receptor Expression in the Endocrine Pancreas
Mol. Endocrinol., October 1, 2008; 22(10): 2353 - 2363.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
W.-J. Song, W. E. Schreiber, E. Zhong, F.-F. Liu, B. D. Kornfeld, F. E. Wondisford, and M. A. Hussain
Exendin-4 Stimulation of Cyclin A2 in {beta}-Cell Proliferation
Diabetes, September 1, 2008; 57(9): 2371 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. M. DeAngelis, G. Heinrich, T. Dai, T. A. Bowman, P. R. Patel, S. J. Lee, E.-G. Hong, D. Y. Jung, A. Assmann, R. N. Kulkarni, et al.
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1: A Link Between Insulin and Lipid Metabolism
Diabetes, September 1, 2008; 57(9): 2296 - 2303.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Epardaud, K. G. Elpek, M. P. Rubinstein, A.-r. Yonekura, A. Bellemare-Pelletier, R. Bronson, J. A. Hamerman, A. W. Goldrath, and S. J. Turley
Interleukin-15/Interleukin-15R{alpha} Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells
Cancer Res., April 15, 2008; 68(8): 2972 - 2983.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy
Osteocalcin differentially regulates {beta} cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
PNAS, April 1, 2008; 105(13): 5266 - 5270.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. C. Martinez, K. Tanabe, C. Cras-Meneur, N. A. Abumrad, E. Bernal-Mizrachi, and M. A. Permutt
Inhibition of Foxo1 Protects Pancreatic Islet {beta}-Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis
Diabetes, April 1, 2008; 57(4): 846 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Shibasaki, H. Takahashi, T. Miki, Y. Sunaga, K. Matsumura, M. Yamanaka, C. Zhang, A. Tamamoto, T. Satoh, J.-i. Miyazaki, et al.
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
PNAS, December 4, 2007; 104(49): 19333 - 19338.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. I. Oprescu, G. Bikopoulos, A. Naassan, E. M. Allister, C. Tang, E. Park, H. Uchino, G. F. Lewis, I. G. Fantus, M. Rozakis-Adcock, et al.
Free Fatty Acid Induced Reduction in Glucose-Stimulated Insulin Secretion: Evidence for a Role of Oxidative Stress In Vitro and In Vivo
Diabetes, December 1, 2007; 56(12): 2927 - 2937.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. K. Karnik, H. Chen, G. W. McLean, J. J. Heit, X. Gu, A. Y. Zhang, M. Fontaine, M. H. Yen, and S. K. Kim
Menin Controls Growth of Pancreatic {beta}-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus
Science, November 2, 2007; 318(5851): 806 - 809.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
G. Zhang, H. Hirai, T. Cai, J. Miura, P. Yu, H. Huang, M. R Schiller, W. D Swaim, R. D Leapman, and A. L Notkins
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose
J. Endocrinol., November 1, 2007; 195(2): 313 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T.-a. Matsuoka, H. Kaneto, R. Stein, T. Miyatsuka, D. Kawamori, E. Henderson, I. Kojima, M. Matsuhisa, M. Hori, and Y. Yamasaki
MafA Regulates Expression of Genes Important to Islet {beta}-Cell Function
Mol. Endocrinol., November 1, 2007; 21(11): 2764 - 2774.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S.-i. Han, S. Aramata, K. Yasuda, and K. Kataoka
MafA Stability in Pancreatic {beta} Cells Is Regulated by Glucose and Is Dependent on Its Constitutive Phosphorylation at Multiple Sites by Glycogen Synthase Kinase 3
Mol. Cell. Biol., October 1, 2007; 27(19): 6593 - 6605.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. A. Glauser and W. Schlegel
Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic {beta} cells
FASEB J, October 1, 2007; 21(12): 3240 - 3249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Pugazhenthi, L. Akhov, G. Selvaraj, M. Wang, and J. Alam
Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E645 - E655.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. H. Ossipov, I. Bazov, L. R. Gardell, J. Kowal, T. Yakovleva, I. Usynin, T. J. Ekstrom, F. Porreca, and G. Bakalkin
Control of Chronic Pain by the Ubiquitin Proteasome System in the Spinal Cord
J. Neurosci., August 1, 2007; 27(31): 8226 - 8237.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Z. H. Nemeth, D. Bleich, B. Csoka, P. Pacher, J. G. Mabley, L. Himer, E. S. Vizi, E. A. Deitch, C. Szabo, B. N. Cronstein, et al.
Adenosine receptor activation ameliorates type 1 diabetes
FASEB J, August 1, 2007; 21(10): 2379 - 2388.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Baroukh, M. A. Ravier, M. K. Loder, E. V. Hill, A. Bounacer, R. Scharfmann, G. A. Rutter, and E. Van Obberghen
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic beta-Cell Lines
J. Biol. Chem., July 6, 2007; 282(27): 19575 - 19588.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Shigeto, M. Katsura, M. Matsuda, S. Ohkuma, and K. Kaku
Nateglinide and Mitiglinide, but Not Sulfonylureas, Induce Insulin Secretion through a Mechanism Mediated by Calcium Release from Endoplasmic Reticulum
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 1 - 7.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Johnson, R. M. Shepherd, D. Gill, T. Gorman, D. M. Smith, and M. J. Dunne
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
Diabetes, June 1, 2007; 56(6): 1694 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Kitiphongspattana, T. A. Khan, K. Ishii-Schrade, M. W. Roe, L. H. Philipson, and H. R. Gaskins
Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1543 - E1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. S. Andrali, Q. Qian, and S. Ozcan
Glucose Mediates the Translocation of NeuroD1 by O-Linked Glycosylation
J. Biol. Chem., May 25, 2007; 282(21): 15589 - 15596.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. C. Rulifson, S. K. Karnik, P. W. Heiser, D. ten Berge, H. Chen, X. Gu, M. M. Taketo, R. Nusse, M. Hebrok, and S. K. Kim
Wnt signaling regulates pancreatic beta cell proliferation
PNAS, April 10, 2007; 104(15): 6247 - 6252.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Li, P. Chen, J. Vaughan, K.-F. Lee, and W. Vale
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
PNAS, March 6, 2007; 104(10): 4206 - 4211.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Eto, V. Kaur, and M. K. Thomas
Regulation of Pancreas Duodenum Homeobox-1 Expression by Early Growth Response-1
J. Biol. Chem., March 2, 2007; 282(9): 5973 - 5983.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Miele, G. A. Raciti, A. Cassese, C. Romano, F. Giacco, F. Oriente, F. Paturzo, F. Andreozzi, A. Zabatta, G. Troncone, et al.
PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic {beta}-Cells
Diabetes, March 1, 2007; 56(3): 622 - 633.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Thore, A. Wuttke, and A. Tengholm
Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca2+ and the ATP-to-ADP Ratio
Diabetes, March 1, 2007; 56(3): 818 - 826.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Stosic-Grujicic, I. Cvetkovic, K. Mangano, M. Fresta, D. Maksimovic-Ivanic, L. Harhaji, D. Popadic, M. Momcilovic, D. Miljkovic, J. Kim, et al.
A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice
J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1038 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. F. Jeans, P. L. Oliver, R. Johnson, M. Capogna, J. Vikman, Z. Molnar, A. Babbs, C. J. Partridge, A. Salehi, M. Bengtsson, et al.
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse
PNAS, February 13, 2007; 104(7): 2431 - 2436.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Pissios, U. Ozcan, E. Kokkotou, T. Okada, C. W. Liew, S. Liu, J. N. Peters, G. Dahlgren, J. Karamchandani, Y. C. Kudva, et al.
Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth
Diabetes, February 1, 2007; 56(2): 311 - 319.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. L. Vanderford, S. S. Andrali, and S. Ozcan
Glucose Induces MafA Expression in Pancreatic Beta Cell Lines via the Hexosamine Biosynthetic Pathway
J. Biol. Chem., January 19, 2007; 282(3): 1577 - 1584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. Takano, Y. Tabata, Y. Kitao, R. Murakami, H. Suzuki, M. Yamada, M. Iinuma, Y. Yoneda, S. Ogawa, and O. Hori
Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C353 - C361.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. I. Hagren and A. Tengholm
Glucose and Insulin Synergistically Activate Phosphatidylinositol 3-Kinase to Trigger Oscillations of Phosphatidylinositol 3,4,5-Trisphosphate in beta-Cells
J. Biol. Chem., December 22, 2006; 281(51): 39121 - 39127.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. O'Driscoll, P. Gammell, E. McKiernan, E. Ryan, P. B. Jeppesen, S. Rani, and M. Clynes
Phenotypic and global gene expression profile changes between low passage and high passage MIN-6 cells
J. Endocrinol., December 1, 2006; 191(3): 665 - 676.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. da Silva Xavier, G. A. Rutter, F. Diraison, C. Andreolas, and I. Leclerc
ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic {beta}-cells
J. Lipid Res., November 1, 2006; 47(11): 2482 - 2491.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Mirasierra and M. Vallejo
The Homeoprotein Alx3 Expressed in Pancreatic ss-Cells Regulates Insulin Gene Transcription by Interacting with the Basic Helix-Loop-Helix Protein E47
Mol. Endocrinol., November 1, 2006; 20(11): 2876 - 2889.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
T. Yakovleva, I. Bazov, G. Cebers, Z. Marinova, Y. Hara, A. Ahmed, M. Vlaskovska, B. Johansson, U. Hochgeschwender, I. N. Singh, et al.
Prodynorphin storage and processing in axon terminals and dendrites
FASEB J, October 1, 2006; 20(12): 2124 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E. Gray, D. Muller, P. E Squires, H. Asare-Anane, G.-C. Huang, S. Amiel, S. J Persaud, and P. M Jones
Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.
J. Endocrinol., September 1, 2006; 190(3): 703 - 710.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. Nielsen, L. Grontved, H. G. Stunnenberg, and S. Mandrup
Peroxisome Proliferator-Activated Receptor Subtype- and Cell-Type-Specific Activation of Genomic Target Genes upon Adenoviral Transgene Delivery
Mol. Cell. Biol., August 1, 2006; 26(15): 5698 - 5714.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. I. Ludowyke, Z. Elgundi, T. Kranenburg, J. R. Stehn, C. Schmitz-Peiffer, W. E. Hughes, and T. J. Biden
Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser1917 Is Mediated by Protein Kinase CbetaII and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells
J. Immunol., August 1, 2006; 177(3): 1492 - 1499.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Marz, J. Stetefeld, K. Bendfeldt, C. Nitsch, J. Reinstein, R. L. Shoeman, B. Dimitriades-Schmutz, M. Schwager, D. Leiser, S. Ozcan, et al.
Ataxin-10 Interacts with O-Linked beta-N-Acetylglucosamine Transferase in the Brain
J. Biol. Chem., July 21, 2006; 281(29): 20263 - 20270.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Kanno, K. Kim, K. Kono, K. M. Drescher, N. M. Chapman, and S. Tracy
Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency.
J. Virol., June 1, 2006; 80(11): 5637 - 5643.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
O. Hori, M. Miyazaki, T. Tamatani, K. Ozawa, K. Takano, M. Okabe, M. Ikawa, E. Hartmann, P. Mai, D. M. Stern, et al.
Deletion of SERP1/RAMP4, a Component of the Endoplasmic Reticulum (ER) Translocation Sites, Leads to ER Stress.
Mol. Cell. Biol., June 1, 2006; 26(11): 4257 - 4267.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. C. Martinez, C. Cras-Meneur, E. Bernal-Mizrachi, and M. A. Permutt
Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet {beta}-cell
Diabetes, June 1, 2006; 55(6): 1581 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. Yamada, H. Ishihara, A. Tamura, R. Takahashi, S. Yamaguchi, D. Takei, A. Tokita, C. Satake, F. Tashiro, H. Katagiri, et al.
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic {beta}-cells
Hum. Mol. Genet., May 15, 2006; 15(10): 1600 - 1609.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
V. Cirulli, J. Zalatan, M. McMaster, R. Prinsen, D. R. Salomon, C. Ricordi, B. E. Torbett, P. Meda, and L. Crisa
The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G.
Diabetes, May 1, 2006; 55(5): 1214 - 1222.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Daunt, O. Dale, and P. A. Smith
Somatostatin Inhibits Oxidative Respiration in Pancreatic {beta}-Cells
Endocrinology, March 1, 2006; 147(3): 1527 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. D. Feng, Z. Luo, S.-g. Roh, M. Hernandez, N. Tawadros, D. J. Keating, and C. Chen
Reduction in Voltage-Gated K+ Currents in Primary Cultured Rat Pancreatic {beta}-Cells by Linoleic Acids
Endocrinology, February 1, 2006; 147(2): 674 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. S. Finlin, A. L. Mosley, S. M. Crump, R. N. Correll, S. Ozcan, J. Satin, and D. A. Andres
Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by the Rem2 GTPase
J. Biol. Chem., December 23, 2005; 280(51): 41864 - 41871.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Iguchi, Y. Ikeda, M. Okamura, T. Tanaka, Y. Urashima, H. Ohguchi, S. Takayasu, N. Kojima, S. Iwasaki, R. Ohashi, et al.
SOX6 Attenuates Glucose-stimulated Insulin Secretion by Repressing PDX1 Transcriptional Actvity and Is Down-regulated in Hyperinsulinemic Obese Mice
J. Biol. Chem., November 11, 2005; 280(45): 37669 - 37680.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. K. Karnik, C. M. Hughes, X. Gu, O. Rozenblatt-Rosen, G. W. McLean, Y. Xiong, M. Meyerson, and S. K. Kim
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
PNAS, October 11, 2005; 102(41): 14659 - 14664.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Bengtsson, A. Stahlberg, P. Rorsman, and M. Kubista
Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels
Genome Res., October 1, 2005; 15(10): 1388 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Thore, O. Dyachok, E. Gylfe, and A. Tengholm
Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting {beta}-cells
J. Cell Sci., October 1, 2005; 118(19): 4463 - 4471.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Tsuboi, M. A. Ravier, H. Xie, M.-A. Ewart, G. W. Gould, S. A. Baldwin, and G. A. Rutter
Mammalian Exocyst Complex Is Required for the Docking Step of Insulin Vesicle Exocytosis
J. Biol. Chem., July 8, 2005; 280(27): 25565 - 25570.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
K. Ueda, J. Kawano, K. Takeda, T. Yujiri, K. Tanabe, T. Anno, M. Akiyama, J. Nozaki, T. Yoshinaga, A. Koizumi, et al.
Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic {beta}-cells via transcriptional activation
Eur. J. Endocrinol., July 1, 2005; 153(1): 167 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Ohara-Imaizumi, T. Ohtsuka, S. Matsushima, Y. Akimoto, C. Nishiwaki, Y. Nakamichi, T. Kikuta, S. Nagai, H. Kawakami, T. Watanabe, et al.
ELKS, a Protein Structurally Related to the Active Zone-associated Protein CAST, Is Expressed in Pancreatic {beta} Cells and Functions in Insulin Exocytosis: Interaction of ELKS with Exocytotic Machinery Analyzed by Total Internal Reflection Fluorescence Microscopy
Mol. Biol. Cell, July 1, 2005; 16(7): 3289 - 3300.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Masur, E. C. Tibaduiza, C. Chen, B. Ligon, and M. Beinborn
Basal Receptor Activation by Locally Produced Glucagon-Like Peptide-1 Contributes to Maintaining {beta}-Cell Function
Mol. Endocrinol., May 1, 2005; 19(5): 1373 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Iype, J. Francis, J. C. Garmey, J. C. Schisler, R. Nesher, G. C. Weir, T. C. Becker, C. B. Newgard, S. C. Griffen, and R. G. Mirmira
Mechanism of insulin Gene Regulation by the Pancreatic Transcription Factor Pdx-1: APPLICATION OF PRE-mRNA ANALYSIS AND CHROMATIN IMMUNOPRECIPITATION TO ASSESS FORMATION OF FUNCTIONAL TRANSCRIPTIONAL COMPLEXES
J. Biol. Chem., April 29, 2005; 280(17): 16798 - 16807.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Kitiphongspattana, C. E. Mathews, E. H. Leiter, and H. R. Gaskins
Proteasome Inhibition Alters Glucose-stimulated (Pro)insulin Secretion and Turnover in Pancreatic {beta}-Cells
J. Biol. Chem., April 22, 2005; 280(16): 15727 - 15734.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Srinivasan, M. Ohsugi, Z. Liu, S. Fatrai, E. Bernal-Mizrachi, and M. A. Permutt
Endoplasmic Reticulum Stress-Induced Apoptosis Is Partly Mediated by Reduced Insulin Signaling Through Phosphatidylinositol 3-Kinase/Akt and Increased Glycogen Synthase Kinase-3{beta} in Mouse Insulinoma Cells
Diabetes, April 1, 2005; 54(4): 968 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Ritz-Laser, A. Mamin, T. Brun, I. Avril, V. M. Schwitzgebel, and J. Philippe
The Zinc Finger-Containing Transcription Factor Gata-4 Is Expressed in the Developing Endocrine Pancreas and Acti