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Department of Psychiatry (P.A.R., M.M.H., R.J.S., S.C.W.) College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0559; and Institute of Veterinary Physiology (T.A.L.), University of Zürich, CH 8057 Zürich, Switzerland
Address all correspondence and requests for reprints to: Paul A. Rushing, Ph.D., University of Cincinnati, College of Medicine, Department of Psychiatry, Cincinnati, Ohio 45267-0559.
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In one experiment, separate groups of ad lib-fed male Long Evans rats were given one i3vt infusion (3 µl over 30 s) of synthetic cerebrospinal fluid vehicle or 1 to 100 pmol amylin, and food intake and body weight were monitored for 7 days. Amylin potently and dose-dependently reduced 1-h food intake, with all doses producing significant reductions. The largest dose (100 pmol) significantly reduced 24-h intake by over 30%. The effect was persistent in that both 7-day cumulative food intake and body weight change were significantly decreased over the 7 days following a single injection of 100 pmol of amylin.
Other groups of rats received continuous i3vt infusion (0.5 µl/h volume) of saline or 2.0 pmol/h amylin via osmotic minipumps over 10 days. Food intake over the 10-day infusion was significantly suppressed in amylin-treated rats as compared to that of controls. Consequently, by the 4th day of infusion, amylin rats weighed significantly less than baseline relative to saline controls, and this difference persisted throughout the remainder of the infusion period. At sacrifice (Day 10), the percent of body weight from retroperitoneal fat depots was significantly lower in the amylin-treated rats, indicative of a reduction of total body adiposity.
In summary, the results support the hypothesis that amylin acts as a signal to the brain contributing to the maintenance of long-term energy balance.
Received October 7, 1999.
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