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Neuropeptide Y Lowers Blood Glucose in Anaesthetized Rats via a Y₅ Receptor Subtype

Medizinische Klinik, Klinikum Essen, 45122 Essen, Germany

Address all correspondence and requests for reprints to: Martin C. Michel, M.D., Universitätsklinikum Essen, Nephrol. Lab. IG 1, Klinikum, Hufelandstrasse 55, Essen 45122, Germany.

	Abstract

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We have investigated the receptor subtype mediating effects of neuropeptide Y (NPY) on blood glucose concentrations. In anaesthetized rats a 120 min i.v. infusion of 2 µg/kg/min NPY lowered blood glucose by 26 mg/dl. This was mimicked by the same dose of peptide YY (PYY), NPY_2-36, PYY_3-36 and [Leu³¹,Pro³⁴] NPY but not by NPY_13-36, PYY_13-36 or rat or human pancreatic polypeptide. The effects of NPY and [Leu³¹,Pro³⁴]NPY were not inhibited by 10 µg/kg/min BIBP 3226. Neither treatment significantly altered plasma insulin concentrations. We conclude that NPY lowers blood glucose concentrations via a Y₅ receptor subtype, i.e. a subtype which has also been implicated in stimulation of food intake.

Received November 7, 1997.

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This Article Abstract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bischoff, A. Articles by Michel, M. C. Search for Related Content PubMed PubMed Citation Articles by Bischoff, A. Articles by Michel, M. C.