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Endocrinology, Vol 99, 1415-1418, Copyright © 1976 by Endocrine Society

ARTICLES

Decreased pancreatic somatostatin (SRIF) concentration in spontaneously diabetic mice

YC Patel, L Orci, A Bankier and DP Cameron

Spontaneously diabetic C57BL/6J obob and C57BL/Ks dbdb mice have been shown to have significantly decreased immunoassayable pancreatic somatostatin concentrations compared to lean littermate controls at 11- 12 weeks: obob 1.06+/-0.15 pg/mug protein (n=10) vs control 1.94+/-0.-6 pg/mug protein (n=10) (mean +/- SE; p less than 0.005); dbdb 0.7+/-0.2 pg/mug protein (n=8) vs control 1.5+/-0.2 pg/mug protein (n=8) (mean +/- SE; p less than 0.005). An inverse relationship between circulating insulin levels and pancreatic SRIF concentration is suggested.


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 DiabetesHome page
S. Julien, J. Laine, and J. Morisset
Regulation of Rat Pancreatic CCKB Receptor and Somatostatin Expression by Insulin
Diabetes, June 1, 2004; 53(6): 1526 - 1534.
[Abstract] [Full Text] [PDF]

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Y. Patel, D. Cameron, Y Stefan, F Malaisse-Lagae, and L Orci
Somatostatin: widespread abnormality in tissues of spontaneously diabetic mice
Science, December 2, 1977; 198(4320): 930 - 931.
[Abstract] [PDF]


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