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Endocrinology, Vol 99, 1333-1335, Copyright © 1976 by Endocrine Society

ARTICLES

Serum immunoreactive relaxin and softening of the uterine cervix in pregnant hamsters

EM O'byrne, WK Sawyer, MC Butler and BG Steinetz

Serum immunoreactive relaxin levels and ripening of the cervix were measured throughout pregnancy in hamsters. RIA relaxin rose from an undetectable level on day 7 to a maximum value of 29 ng/ml on day 15 of gestation and then fell prior to parturition. The cervix became progressively more dilatable from the 12th to the 16th day of pregnancy. It is suggested that the endogenous relaxin measured by RIA may induce the cervical softening. The absolute levels of immunoreactive relaxin appear to be 10 to 15-fold higher than those previously observed in rats, mice and guinea pigs.


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R. H. Renegar and C. R. Owens III
Measurement of Plasma and Tissue Relaxin Concentrations in the Pregnant Hamster and Fetus Using a Homologous Radioimmunoassay
Biol Reprod, August 1, 2002; 67(2): 500 - 505.
[Abstract] [Full Text] [PDF]


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