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Endocrinology, Vol 99, 910-913, Copyright © 1976 by Endocrine Society

ARTICLES

Inhibition of calcium uptake by somatostatin in isolated rat islets of Langerhans

JR Oliver

Somatostatin (1 mug/ml) inhibited glucose (16.7 mM)-stimulated 45Ca uptake by isolated rat islets incubated in media containing no added calcium or calcium at a low concentration (0.2mM). Epinephrine (50 mug/ml) and mannoheptulose (20mM) also inhibited 45Ca uptake by islets incubated in the presence of calcium (0.2mM). Addition of glucose (16.7 mM) caused a small but significant increase in insulin release from islets incubated in media containing no added calcium. In the presence of a low concentration of calcium (0.2 mM), glucose caused a much greater increase in insulin secretion which was inhibited by addition of somatostatin, epinephrine or mannoheptulose.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1976 by The Endocrine Society