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Endocrinology, Vol 99, 641-644, Copyright © 1976 by Endocrine Society

ARTICLES

Presence of melatonin in plasma and urine or pinealectomized rats

Y Ozaki and HJ Lynch

Melatonin was shown to occur in rat plasma and urine after pinealectomy by bioassay, radioimmunoassay, and thin-layer chromatography. Total daily excretion of melatonin in pinealectomized rats was about 20% of control. Light-dark rhythms of plasma melatonin levels and urinary excretion rates disappeared after pinealectomy.


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