This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Glass, D. A. Articles by Karsenty, G. Search for Related Content PubMed PubMed Citation Articles by Glass, D. A., II Articles by Karsenty, G.

In Vivo Analysis of Wnt Signaling in Bone

Medical Scientist Training Program (D.A.G.), Baylor College of Medicine, Houston, Texas 77030; and Department of Genetics and Development (G.K.), Columbia University Medical Center, New York, New York 10032

Address all correspondence and requests for reprints to: Gerard Karsenty, Department of Genetics and Development, Columbia University Medical Center, 701 West 168th Street, Room 1602A, New York, New York 10032. E-mail: gk2172{at}columbia.edu.

Bone remodeling requires osteoblasts and osteoclasts working in concert to maintain a constant bone mass. The dysregulation of signaling pathways that affect osteoblast or osteoclast differentiation or function leads to either osteopenia or high bone mass. The discovery that activating and inactivating mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, led to high bone mass and low bone mass in human beings, respectively, generated a tremendous amount of interest in the possible role of the Wnt signaling pathway in the regulation of bone remodeling. A number of mouse models have been generated to study a collection of Wnt signaling molecules that have been identified as regulators of bone mass. These mouse models help establish the canonical Wnt signaling pathway as a major regulator of chondrogenesis, osteoblastogenesis, and osteoclastogenesis. This review will summarize these advances.

This article has been cited by other articles:

				R. Modarresi, Z. Xiang, M. Yin, and J. Laurence WNT/{beta}-Catenin Signaling Is Involved in Regulation of Osteoclast Differentiation by Human Immunodeficiency Virus Protease Inhibitor Ritonavir: Relationship to Human Immunodeficiency Virus-Linked Bone Mineral Loss Am. J. Pathol., January 1, 2009; 174(1): 123 - 135. [Abstract] [Full Text] [PDF]

				K. M. Middleton, S. A. Kelly, and T. Garland Jr Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice Integr. Comp. Biol., June 18, 2008; (2008) icn057v1. [Abstract] [Full Text] [PDF]

				D. A. Towler Vascular Calcification: A Perspective On An Imminent Disease Epidemic IBMS BoneKEy, February 1, 2008; 5(2): 41 - 58. [Abstract] [Full Text] [PDF]

				P. Hayward, T. Kalmar, and A. Martinez Arias Wnt/Notch signalling and information processing during development Development, February 1, 2008; 135(3): 411 - 424. [Abstract] [Full Text] [PDF]

				T. J. Martin and K. W. Ng New Agents for the Treatment of Osteoporosis IBMS BoneKEy, November 1, 2007; 4(11): 287 - 298. [Abstract] [Full Text] [PDF]