| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pharmacology (R.N., P.W., M.T., A.S., H.-G.J.), German Institute of Human Nutrition, D-14558 Potsdam-Rehbruecke, Germany; Department of Psychiatry (P.P., D.P.-T., T.R.C., M.T.), University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237; Department of Physiology (S.T., M.J.V., C.D.), University of Santiago de Compostela, 15781 Santiago de Compostela, Spain; Physiology and Animal Husbandry (M.A., W.L.), Institute of Animal Sciences, ETH Zurich, 8603 Schwerzenbach, Switzerland; Energy Balance and Obesity Division (S.M., A.M., L.M.W.), Rowett Research Institute, Aberdeen AB21 9SB, United Kingdom; and Department of Chemistry (R.D.), Indiana University, Bloomington, Indiana 47405
Address all correspondence and requests for reprints to: Prof. Carlos Diéguez, Department of Physiology, University of Santiago de Compostela, School of Medicine, C/S, Francisco 1, 15705 Santiago de Compostela, Spain. E-mail: fscadigo{at}usc.es.
Ghrelin stimulates food intake and adiposity and thereby increases body weight (BW) in rodents after central as well as peripheral administration. Recently, it was discovered that the gene precursor of ghrelin encoded another secreted and bioactive peptide named obestatin. First reports appeared to demonstrate that this peptide requires an amidation for its biological activity and acts through the orphan receptor, GPR-39. Obestatin was shown to have actions opposite to ghrelin on food intake, BW, and gastric emptying. In the present study, we failed to observe any effect of obestatin on food intake, BW, body composition, energy expenditure, locomotor activity, respiratory quotient, or hypothalamic neuropeptides involved in energy balance regulation. In agreement with the first report, we were unable to find any effect of obestatin on GH secretion in vivo. Moreover, we were unable to find mRNA expression of GPR-39, the putative obestatin receptor, in the hypothalamus of rats. Therefore, the results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance.
This article has been cited by other articles:
 |
|
 |
|
  J. V. Zhang, H. Jahr, C.-W. Luo, C. Klein, K. Van Kolen, L. Ver Donck, A. De, E. Baart, J. Li, D. Moechars, et al. Obestatin Induction of Early-Response Gene Expression in Gastrointestinal and Adipose Tissues and the Mediatory Role of G Protein-Coupled Receptor, GPR39 Mol. Endocrinol., June 1, 2008; 22(6): 1464 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ataka, A. Inui, A. Asakawa, I. Kato, and M. Fujimiya Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1210 - G1218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Reed, S. C. Benoit, P. T. Pfluger, M. H. Tschop, D. A. D'Alessio, and R. J. Seeley Mice with chronically increased circulating ghrelin develop age-related glucose intolerance Am J Physiol Endocrinol Metab, April 1, 2008; 294(4): E752 - E760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K Samson, G. L C Yosten, J.-K. Chang, A. V Ferguson, and M. M White Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis J. Endocrinol., March 1, 2008; 196(3): 559 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vicennati, S. Genghini, R. De Iasio, F. Pasqui, U. Pagotto, and R. Pasquali Circulating obestatin levels and the ghrelin/obestatin ratio in obese women Eur. J. Endocrinol., September 1, 2007; 157(3): 295 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Garg The Ongoing Saga of Obestatin: Is It a Hormone? J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3396 - 3398. [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Richards and M. Proszkowiec-Weglarz Mechanisms Regulating Feed Intake, Energy Expenditure, and Body Weight in Poultry Poult. Sci., July 1, 2007; 86(7): 1478 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-F. Guo, X. Zheng, Y.-W. Qin, J.-Q. Hu, S.-P. Chen, and Z. Zhang Circulating Preprandial Ghrelin to Obestatin Ratio Is Increased in Human Obesity J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1875 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zizzari, R. Longchamps, J. Epelbaum, and M. T. Bluet-Pajot Obestatin Partially Affects Ghrelin Stimulation of Food Intake and Growth Hormone Secretion in Rodents Endocrinology, April 1, 2007; 148(4): 1648 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Zhang, C. Klein, P.-G. Ren, S. Kass, L. V. Donck, D. Moechars, and A. J. W. Hsueh Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake" Science, February 9, 2007; 315(5813): 766d - 766d. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Holst, K. L. Egerod, E. Schild, S. P. Vickers, S. Cheetham, L.-O. Gerlach, L. Storjohann, C. E. Stidsen, R. Jones, A. G. Beck-Sickinger, et al. GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin Endocrinology, January 1, 2007; 148(1): 13 - 20. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
