help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology, doi:10.1210/en.2004-1576
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
146/3/1025    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Habener, J. F.
Right arrow Articles by Thomas, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Habener, J. F.
Right arrow Articles by Thomas, M. K.
Endocrinology Vol. 146, No. 3 1025-1034
Copyright © 2005 by The Endocrine Society

MINIREVIEW

Minireview: Transcriptional Regulation in Pancreatic Development

Joel F. Habener, Daniel M. Kemp and Melissa K. Thomas

Laboratory of Molecular Endocrinology, Massachusetts General Hospital (J.F.H., M.K.T.), Howard Hughes Medical Institute (J.F.H.), Harvard Medical School (J.F.H., M.K.T.), Boston, Massachusetts 02114; and Novartis Institutes for BioMedical Research (D.M.K.), Cambridge, Massachusetts 02139

Address all correspondence and requests for reprints to: Dr. Joel F. Habener, Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street, WEL320, Boston, Massachusetts 02114. E-mail: jhabener{at}partners.org.

Abstract

Considerable progress has been made in the understanding of the sequential activation of signal transduction pathways and the expression of transcription factors during pancreas development. Much of this understanding has been obtained by analyses of the phenotypes of mice in which the expression of key genes has been disrupted (knockout mice). Knockout of the genes for Pdx1, Hlxb9, Isl1, or Hex results in an arrest of pancreas development at a very early stage (embryonic d 8–9). Disruption of genes encoding components of the Notch signaling pathway, e.g. Hes1 or neurogenin-3, abrogates development of the endocrine pancreas (islets of Langerhans). Disruption of transcription factor genes expressed more downstream in the developmental cascade (Beta2/NeuroD, Pax4, NKx2.2, and Nkx6.1) curtails the formation of insulin-producing ß-cells. An understanding of the importance of transcription factor genes during pancreas development has provided insights into the pathogenesis of diabetes, in which the mass of insulin-producing ß-cells is reduced.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
T. Jin
Mechanisms underlying proglucagon gene expression
J. Endocrinol., July 1, 2008; 198(1): 17 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Mukhi, J. Mao, and D. D. Brown
Remodeling the exocrine pancreas at metamorphosis in Xenopus laevis
PNAS, July 1, 2008; 105(26): 8962 - 8967.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Chen, K. Hussain, M. Al-Ali, M. T. Dattani, P. Hindmarsh, P. M. Jones, and P. Marsh
Neonatal and Late-Onset Diabetes Mellitus Caused by Failure of Pancreatic Development: Report of 4 More Cases and a Review of the Literature
Pediatrics, June 1, 2008; 121(6): e1541 - e1547.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. C. Schisler, P. T. Fueger, D. A. Babu, H. E. Hohmeier, J. S. Tessem, D. Lu, T. C. Becker, B. Naziruddin, M. Levy, R. G. Mirmira, et al.
Stimulation of Human and Rat Islet {beta}-Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1
Mol. Cell. Biol., May 15, 2008; 28(10): 3465 - 3476.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. Aguilar-Bryan and J. Bryan
Neonatal Diabetes Mellitus
Endocr. Rev., May 1, 2008; 29(3): 265 - 291.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. White, C. Lee May, R. N. Lamounier, J. E. Brestelli, and K. H. Kaestner
Defining Pancreatic Endocrine Precursors and Their Descendants
Diabetes, March 1, 2008; 57(3): 654 - 668.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. J. Doyle and L. Sussel
Nkx2.2 Regulates {beta}-Cell Function in the Mature Islet
Diabetes, August 1, 2007; 56(8): 1999 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Jiang, M. Au, K. Lu, A. Eshpeter, G. Korbutt, G. Fisk, and A. S. Majumdar
Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem Cells
Stem Cells, August 1, 2007; 25(8): 1940 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Plengvidhya, S. Kooptiwut, N. Songtawee, A. Doi, H. Furuta, M. Nishi, K. Nanjo, W. Tantibhedhyangkul, W. Boonyasrisawat, P.-t. Yenchitsomanus, et al.
PAX4 Mutations in Thais with Maturity Onset Diabetes of the Young
J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2821 - 2826.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. K. Mfopou, V. De Groote, X. Xu, H. Heimberg, and L. Bouwens
Sonic Hedgehog and Other Soluble Factors from Differentiating Embryoid Bodies Inhibit Pancreas Development
Stem Cells, May 1, 2007; 25(5): 1156 - 1165.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Mussmann, M. Geese, F. Harder, S. Kegel, U. Andag, A. Lomow, U. Burk, D. Onichtchouk, C. Dohrmann, and M. Austen
Inhibition of GSK3 Promotes Replication and Survival of Pancreatic Beta Cells
J. Biol. Chem., April 20, 2007; 282(16): 12030 - 12037.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Ait-Lounis, D. Baas, E. Barras, C. Benadiba, A. Charollais, R. Nlend Nlend, D. Liegeois, P. Meda, B. Durand, and W. Reith
Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas
Diabetes, April 1, 2007; 56(4): 950 - 959.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. J. Doyle, Z. L. Loomis, and L. Sussel
Nkx2.2-repressor activity is sufficient to specify {alpha}-cells and a small number of {beta}-cells in the pancreatic islet
Development, February 1, 2007; 134(3): 515 - 523.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. A. Moibi, D. Gupta, T. L. Jetton, M. Peshavaria, R. Desai, and J. L. Leahy
Peroxisome Proliferator-Activated Receptor-{gamma} Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells
Diabetes, January 1, 2007; 56(1): 88 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M. E Cerf
Transcription factors regulating {beta}-cell function.
Eur. J. Endocrinol., November 1, 2006; 155(5): 671 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. S. Gierl, N. Karoulias, H. Wende, M. Strehle, and C. Birchmeier
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
Genes & Dev., September 1, 2006; 20(17): 2465 - 2478.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Hua, Y.-Q. Zhang, S. Dabernat, M. Kritzik, D. Dietz, L. Sterling, and N. Sarvetnick
BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2
J. Biol. Chem., May 12, 2006; 281(19): 13574 - 13580.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Thyssen, E. Arany, and D. J. Hill
Ontogeny of Regeneration of {beta}-Cells in the Neonatal Rat after Treatment with Streptozotocin
Endocrinology, May 1, 2006; 147(5): 2346 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Luo, S. M. Liu, H. Liu, Q. Li, Q. Xu, X. Sun, B. Davis, J. Li, and S. Chua Jr.
Allelic Variation on Chromosome 5 Controls {beta}-Cell Mass Expansion during Hyperglycemia in Leptin Receptor-Deficient Diabetes Mice
Endocrinology, May 1, 2006; 147(5): 2287 - 2295.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Wang, T. Liu, Z. Li, X. Ma, and T. Jin
Redundant and Synergistic Effect of Cdx-2 and Brn-4 on Regulating Proglucagon Gene Expression
Endocrinology, April 1, 2006; 147(4): 1950 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. A. Kim, Y. T. Noh, M.-J. Ryu, H.-T. Kim, S.-E. Lee, C.-H. Kim, C. Lee, Y. H. Kim, and C. Y. Choi
Phosphorylation and Transactivation of Pax6 by Homeodomain-interacting Protein Kinase 2
J. Biol. Chem., March 17, 2006; 281(11): 7489 - 7497.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. W. Limesand, P. J. Rozance, G. O. Zerbe, J. C. Hutton, and W. W. Hay Jr.
Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction
Endocrinology, March 1, 2006; 147(3): 1488 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. S. Lee, D. D. De Leon, K. H. Kaestner, and D. A. Stoffers
Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3
Diabetes, February 1, 2006; 55(2): 269 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. D. De Leon, C. Farzad, M. F. Crutchlow, J. Brestelli, J. Tobias, K. H. Kaestner, and D. A. Stoffers
Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment
Physiol Genomics, January 12, 2006; 24(2): 133 - 143.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Francis, S. K. Chakrabarti, J. C. Garmey, and R. G. Mirmira
Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription
J. Biol. Chem., October 28, 2005; 280(43): 36244 - 36253.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Cozar-Castellano and A. F. Stewart
Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy
PNAS, May 31, 2005; 102(22): 7781 - 7782.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society