This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pinent, M. Articles by Ardévol, A. Search for Related Content PubMed PubMed Citation Articles by Pinent, M. Articles by Ardévol, A.

Grape Seed-Derived Procyanidins Have an Antihyperglycemic Effect in Streptozotocin-Induced Diabetic Rats and Insulinomimetic Activity in Insulin-Sensitive Cell Lines

Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43005 Tarragona, Spain

Address all correspondence and requests for reprints to: Dr. Anna Ardévol, Department of Biochemistry and Biotechnology, Plaza Imperial Tarraco 1, 43005 Tarragona, Spain. E-mail: aag{at}astor.urv.es.

Flavonoids are functional constituents of many fruits and vegetables. Some flavonoids have antidiabetic properties because they improve altered glucose and oxidative metabolisms of diabetic states. Procyanidins are flavonoids with an oligomeric structure, and it has been shown that they can improve the pathological oxidative state of a diabetic situation. To evaluate their effects on glucose metabolism, we administered an extract of grape seed procyanidins (PE) orally to streptozotocin-induced diabetic rats. This had an antihyperglycemic effect, which was significantly increased if PE administration was accompanied by a low insulin dose. The antihyperglycemic effect of PE may be partially due to the insulinomimetic activity of procyanidins on insulin-sensitive cell lines. PE stimulated glucose uptake in L6E9 myotubes and 3T3-L1 adipocytes in a dose-dependent manner. Like insulin action, the effect of PE on glucose uptake was sensitive to wortmannin, an inhibitor of phosphoinositol 3-kinase and to SB203580, an inhibitor of p38 MAPK. PE action also stimulated glucose transporter-4 translocation to the plasma membrane. In summary, procyanidins have insulin-like effects in insulin-sensitive cells that could help to explain their antihyperglycemic effect in vivo. These effects must be added to their antioxidant activity to explain why they can improve diabetic situations.

This article has been cited by other articles:

				U. J. Jung, M.-K. Lee, Y. B. Park, S.-M. Jeon, and M.-S. Choi Antihyperglycemic and Antioxidant Properties of Caffeic Acid in db/db Mice J. Pharmacol. Exp. Ther., August 1, 2006; 318(2): 476 - 483. [Abstract] [Full Text] [PDF]

				H.-C. Su, L.-M. Hung, and J.-K. Chen Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1339 - E1346. [Abstract] [Full Text] [PDF]