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Endocrinology Vol. 144, No. 9 3765-3773
Copyright © 2003 by The Endocrine Society

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

Michael W. Rajala and Philipp E. Scherer

Department of Cell Biology (M.W.R., P.E.S.) and Diabetes Research and Training Center (P.E.S.), Albert Einstein College of Medicine, Bronx, New York 10461

Address all correspondence and requests for reprints to: Philipp E. Scherer, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461. E-mail: scherer{at}aecom.yu.edu.

Adipose tissue evolved to efficiently store energy for times of caloric restriction. The large caloric excess common in many Western diets has negated the need for this thrifty function, leaving adipose tissue ill-equipped to handle this increased load. An excess of adipose tissue increases risk for a number of conditions including coronary artery disease, hypertension, dyslipidemias, type 2 diabetes, and even cancer. Indeed, the ability of the adipocyte to function properly when engorged with lipid can lead to lipid accumulation in other tissues, reducing their ability to function and respond normally. The role of adipose tissue as an endocrine organ capable of secreting a number of adipose tissue-specific or enriched hormones, known as adipokines, is gaining appreciation. The normal balance of these adipose tissue secretory proteins is perturbed in obesity. Paradoxically, the lack of normal adipose tissue, as seen in cases of lipodystrophy and lipoatrophy, is also associated with pathologic sequelae similar to what is seen with obesity. The pathologic findings associated with lack of adipose tissue, largely due to inability to properly store lipids, may also be due to a lack of adipokines. In this review, we highlight the role of adipose tissue as an endocrine organ focusing on some of the recent advances in the identification and pharmacological characterization of adipokines as well as their regulation in the context of obesity and insulin-resistant states.




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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
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[Abstract] [Full Text] [PDF]

Home page
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N. P. Nunez, W.-J. Oh, J. Rozenberg, C. Perella, M. Anver, J. C. Barrett, S. N. Perkins, D. Berrigan, J. Moitra, L. Varticovski, et al.
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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The Potential of Adiponectin in Driving Arthritis
J. Immunol., April 1, 2006; 176(7): 4468 - 4478.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
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OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis
J. Lipid Res., February 1, 2006; 47(2): 450 - 460.
[Abstract] [Full Text] [PDF]

Home page
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The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes
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[Abstract] [Full Text] [PDF]

Home page
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LS14: A Novel Human Adipocyte Cell Line that Produces Prolactin
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[Abstract] [Full Text] [PDF]

Home page
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Why Might Thiazolidinediones Increase Exercise Capacity in Patients With Type 2 Diabetes?
Diabetes Care, December 1, 2005; 28(12): 2975 - 2977.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. M. van der Vleuten, L. J. H. van Tits, M. den Heijer, H. Lemmers, A. F. H. Stalenhoef, and J. de Graaf
Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile
J. Lipid Res., November 1, 2005; 46(11): 2398 - 2404.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
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[Full Text] [PDF]

Home page
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Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1807 - H1813.
[Abstract] [Full Text] [PDF]

Home page
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Home page
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Diabetes, September 1, 2005; 54(9): 2620 - 2627.
[Abstract] [Full Text] [PDF]

Home page
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Central and peripheral contributions to obesity-associated hypertension: impact of early overnourishment
Exp Physiol, September 1, 2005; 90(5): 697 - 702.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
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Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R297 - R298.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
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[Full Text] [PDF]

Home page