This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cettour-Rose, P. Articles by Rohner-Jeanrenaud, F. Search for Related Content PubMed PubMed Citation Articles by Cettour-Rose, P. Articles by Rohner-Jeanrenaud, F.

The Leptin-Like Effects of 3-d Peripheral Administration of a Melanocortin Agonist Are More Marked in Genetically Obese Zucker (fa/fa) than in Lean Rats

Department of Medicine, Division of Endocrinology and Diabetology, University of Geneva, Faculty of Medicine, 1211 Geneva 14, Switzerland

Address all correspondence and requests for reprints to: Dr. F. Rohner-Jeanrenaud, Hôpitaux Universitaires de Genève, Division of Endocrinology and Diabetology, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. E-mail: . f.rohner-jeanrenaud{at}hcuge.ch

The effects of a 3-d peripheral administration of an -MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats by comparing MTII-treated animals with two different control groups, one being ad libitum fed, the other pair-fed to the amount of food consumed by MTII-treated rats. MTII treatment of lean and obese rats lowered food intake and body weight, the effects being more marked in obese than in lean rats. In both groups, MTII administration suppressed the increased plasma FFA levels brought about by food restriction. In lean rats, MTII prevented the decrease in brown adipose tissue UCP1, UCP2, and UCP3 expression and muscle UCP3 occurring during food restriction. In obese animals, MTII markedly increased brown adipose tissue (7-fold) and muscle (2.5-fold) UCP3 expression. The decrease in liver carnitine palmitoyltransferase-1 elicited by food restriction in lean and obese rats was prevented by MTII administration. In summary, the effects of MTII resemble those of leptin and are more marked in obese than in lean animals, in keeping with their reported reduced endogenous melanocortin tone. Melanocortin agonists may be useful in the treatment of obesity associated with impaired leptin signaling.

This article has been cited by other articles:

				K A. H Iwen, O. Senyaman, A. Schwartz, M. Drenckhan, B. Meier, D. Hadaschik, and J. Klein Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes J. Endocrinol., March 1, 2008; 196(3): 465 - 472. [Abstract] [Full Text] [PDF]

				V. Tolle and M. J. Low In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice Diabetes, January 1, 2008; 57(1): 86 - 94. [Abstract] [Full Text] [PDF]

				A. D. Strader, H. Shi, R. Ogawa, R. J. Seeley, and O. Reizes The Effects of the Melanocortin Agonist (MT-II) on Subcutaneous and Visceral Adipose Tissue in Rodents J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1153 - 1161. [Abstract] [Full Text] [PDF]

				M. M. Glavas, S. E. Joachim, S. J. Draper, M. S. Smith, and K. L. Grove Melanocortinergic Activation by Melanotan II Inhibits Feeding and Increases Uncoupling Protein 1 Messenger Ribonucleic Acid in the Developing Rat Endocrinology, July 1, 2007; 148(7): 3279 - 3287. [Abstract] [Full Text] [PDF]

				M. Lee, A. Kim, S. C. Chua Jr., S. Obici, and S. L. Wardlaw Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E121 - E131. [Abstract] [Full Text] [PDF]

				G. Li, Y. Zhang, E. Rodrigues, D. Zheng, M. Matheny, K.-Y. Cheng, and P. J. Scarpace Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E252 - E258. [Abstract] [Full Text] [PDF]

				A. Voss-Andreae, J. G. Murphy, K. L. J. Ellacott, R. C. Stuart, E. A. Nillni, R. D. Cone, and W. Fan Role of the Central Melanocortin Circuitry in Adaptive Thermogenesis of Brown Adipose Tissue Endocrinology, April 1, 2007; 148(4): 1550 - 1560. [Abstract] [Full Text] [PDF]

				B. M. Kublaoui, J. L. Holder Jr., T. Gemelli, and A. R. Zinn Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus Neurons Mol. Endocrinol., October 1, 2006; 20(10): 2483 - 2492. [Abstract] [Full Text] [PDF]

				C. K. Song, R. M. Jackson, R. B. S. Harris, D. Richard, and T. J. Bartness Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1467 - R1476. [Abstract] [Full Text] [PDF]

				T. Yasuda, T. Masaki, T. Kakuma, and H. Yoshimatsu Hypothalamic Melanocortin System Regulates Sympathetic Nerve Activity in Brown Adipose Tissue Experimental Biology and Medicine, March 1, 2004; 229(3): 235 - 239. [Abstract] [Full Text] [PDF]

				S. Bluher, M. Ziotopoulou, J. W. Bullen Jr, S. J. Moschos, L. Ungsunan, E. Kokkotou, E. Maratos-Flier, and C. S. Mantzoros Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice Diabetes, January 1, 2004; 53(1): 82 - 90. [Abstract] [Full Text] [PDF]

				K. L. J. Ellacott, C. B. Lawrence, L. E. Pritchard, and S. M. Luckman Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1005 - R1010. [Abstract] [Full Text] [PDF]

				G. Li, C. V. Mobbs, and P. J. Scarpace Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats Diabetes, August 1, 2003; 52(8): 1951 - 1957. [Abstract] [Full Text] [PDF]

				S. Kumano, H. Matsumoto, Y. Takatsu, J. Noguchi, C. Kitada, and T. Ohtaki Changes in Hypothalamic Expression Levels of Galanin-Like Peptide in Rat and Mouse Models Support That It Is a Leptin-Target Peptide Endocrinology, June 1, 2003; 144(6): 2634 - 2643. [Abstract] [Full Text] [PDF]

				H. Shinyama, H. Masuzaki, H. Fang, and J. S. Flier Regulation of Melanocortin-4 Receptor Signaling: Agonist-Mediated Desensitization and Internalization Endocrinology, April 1, 2003; 144(4): 1301 - 1314. [Abstract] [Full Text] [PDF]