This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Li, W. W. Articles by Courtin, F. Search for Related Content PubMed PubMed Citation Articles by Li, W. W. Articles by Courtin, F.

Induction of Type 3 Iodothyronine Deiodinase by Nerve Injury in the Rat Peripheral Nervous System

INSERM, U-488, 94276 Le Kremlin-Bicêtre, France

Address all correspondence and requests for reprints to: Dr. Françoise Courtin, INSERM, U-488, 80 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre Cedex, France. E-mail: courtin{at}kb.inserm.fr

Thyroid hormones are essential for the development and repair of the peripheral nervous system. The type 2 deiodinase, which is responsible for the activation of T₄ into T₃, is induced in injured sciatic nerve. To obtain information on the type 3 deiodinase (D3) responsible for the degradation of thyroid hormones, we looked for its expression (mRNA and activity) in the sciatic nerve after injury. D3 was undetectable in the intact sciatic nerve of adult rats, but was rapidly and highly increased in the distal and proximal segments after nerve lesion. After cryolesion, D3 up-regulation disappeared after 3 d in the proximal segment, whereas it was sustained for 10 d in the distal segment, then declined to reach basal levels after 28 d, when functional recovery was completed. After a transsection preventing the nerve regeneration, up-regulation of D3 persisted up to 28 d at high levels in the distal segment. D3 was expressed in peripheral connective sheaths and in the internal endoneural compartment. D3 mRNA was inducible by 12-O-tetradecanoylphorbol-13-acetate in cultured fibroblasts or Schwann cells. In conclusion, induction of D3 in the peripheral nervous system after injury may play an important role during the regeneration process by adjusting intracellular T₃ levels.

This article has been cited by other articles:

				S. A. Huang Deiodination and Cellular Proliferation: Parallels between Development, Differentiation, Tumorigenesis, and Now Regeneration Endocrinology, January 1, 2009; 150(1): 3 - 4. [Full Text] [PDF]

				B. Gereben, A. M. Zavacki, S. Ribich, B. W. Kim, S. A. Huang, W. S. Simonides, A. Zeold, and A. C. Bianco Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling Endocr. Rev., December 1, 2008; 29(7): 898 - 938. [Abstract] [Full Text] [PDF]

				A. Lamirand, S. Pallud-Mothre, M. Ramauge, M. Pierre, and F. Courtin Oxidative Stress Regulates Type 3 Deiodinase and Type 2 Deiodinase in Cultured Rat Astrocytes Endocrinology, July 1, 2008; 149(7): 3713 - 3721. [Abstract] [Full Text] [PDF]

				S. A. Huang, M. A. Mulcahey, A. Crescenzi, M. Chung, B. W. Kim, C. Barnes, W. Kuijt, H. Turano, J. Harney, and P. R. Larsen Transforming Growth Factor-{beta} Promotes Inactivation of Extracellular Thyroid Hormones via Transcriptional Stimulation of Type 3 Iodothyronine Deiodinase Mol. Endocrinol., December 1, 2005; 19(12): 3126 - 3136. [Abstract] [Full Text] [PDF]