help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adam, C. L.
Right arrow Articles by Mercer, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adam, C. L.
Right arrow Articles by Mercer, J. G.
Endocrinology Vol. 141, No. 12 4349-4356
Copyright © 2000 by The Endocrine Society

ARTICLES

Photoperiod Regulates Growth, Puberty and Hypothalamic Neuropeptide and Receptor Gene Expression in Female Siberian Hamsters1

Clare L. Adam, Kim M. Moar, Tracy J. Logie, Alexander W. Ross, Perry Barrett, Peter J. Morgan and Julian G. Mercer

Molecular Neuroendocrinology Group, Aberdeen Centre for Energy Regulation and Obesity, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom

Address all correspondence and requests for reprints to: Dr. C. L. Adam, Molecular Neuroendocrinology Group, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom. E-mail: cla{at}rri.sari.ac.uk

In seasonal mammals, both the growth and reproductive axes are regulated by photoperiod. Female Siberian hamsters were kept, for up to 12 weeks, in long-day (LD) or short-day (SD) photoperiod, from weaning at 3 weeks of age (Exp 1). LD hamsters had characteristically faster growth and higher asymptotic body weight, adiposity, and leptin gene expression in adipose tissue. Only LD females attained puberty. Gene expression in the hypothalamic arcuate nucleus for leptin receptor (OB-Rb), POMC, and melanocortin 3-receptor (MC3-R) was higher in LD but did not change from weaning levels in SD. In contrast, gene expression in the arcuate nucleus for cocaine and amphetamine-regulated transcript (CART) was higher in SD than LD, a difference that was apparent at 2 weeks post weaning. Transfer of SD females to LD at 15 weeks post weaning (Exp 2) increased body weight, leptin signal, and gene expression for POMC but failed to induce normal puberty onset or to increase gene expression for OB-Rb and MC3-R. Therefore, photoperiodic regulation of puberty may be modulated by age, by photoperiodic history, and by changes in leptin signaling and the activity of the leptin-sensitive hypothalamic melanocortin system (POMC, MC3-R). A role for CART in photoperiodic regulation of growth is suggested, because the changes in CART gene expression preceded significant divergence of growth trajectories in the opposite photoperiods.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Ellis, K. M. Moar, T. J. Logie, A. W. Ross, P. J. Morgan, and J. G. Mercer
Diurnal profiles of hypothalamic energy balance gene expression with photoperiod manipulation in the Siberian hamster, Phodopus sungorus
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1148 - R1153.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
E. W Kabithe and N. J Place
Photoperiod-dependent modulation of anti-Mullerian hormone in female Siberian hamsters, Phodopus sungorus
Reproduction, March 1, 2008; 135(3): 335 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Z. A. Archer, K. M. Moar, T. J. Logie, L. Reilly, V. Stevens, P. J. Morgan, and J. G. Mercer
Hypothalamic neuropeptide gene expression during recovery from food restriction superimposed on short-day photoperiod-induced weight loss in the Siberian hamster
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1094 - R1101.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. H. Jethwa, A. Warner, K. N. Nilaweera, J. M. Brameld, J. W. Keyte, W. G. Carter, N. Bolton, M. Bruggraber, P. J. Morgan, P. Barrett, et al.
VGF-Derived Peptide, TLQP-21, Regulates Food Intake and Body Weight in Siberian Hamsters
Endocrinology, August 1, 2007; 148(8): 4044 - 4055.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Z. A. Archer, J. Corneloup, D. V. Rayner, P. Barrett, K. M. Moar, and J. G. Mercer
Solid and Liquid Obesogenic Diets Induce Obesity and Counter-Regulatory Changes in Hypothalamic Gene Expression in Juvenile Sprague-Dawley Rats
J. Nutr., June 1, 2007; 137(6): 1483 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E. Krol and J. R Speakman
Regulation of body mass and adiposity in the field vole, Microtus agrestis: a model of leptin resistance
J. Endocrinol., February 1, 2007; 192(2): 271 - 278.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M. E Timonin, N. J Place, E. Wanderi, and K. E Wynne-Edwards
Phodopus campbelli detect reduced photoperiod during development but, unlike Phodopus sungorus, retain functional reproductive physiology.
Reproduction, October 1, 2006; 132(4): 661 - 670.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. E Mitchell, R. Nogueiras, K. Rance, D V. Rayner, S. Wood, C. Dieguez, and L. M Williams
Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats.
J. Endocrinol., September 1, 2006; 190(3): 571 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Tups, M. Helwig, S. Stohr, P. Barrett, J. G. Mercer, and M. Klingenspor
Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R643 - R650.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. S. Muhlhausler, C. L. Adam, E. M. Marrocco, P. A. Findlay, C. T. Roberts, J. R. McFarlane, K. G. Kauter, and I. C. McMillen
Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation
J. Physiol., May 15, 2005; 565(1): 185 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. J. Place, C. R. Tuthill, E. E. Schoomer, A. D. Tramontin, and I. Zucker
Short Day Lengths Delay Reproductive Aging
Biol Reprod, September 1, 2004; 71(3): 987 - 992.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Z. A. Archer, D. V. Rayner, and J. G. Mercer
Hypothalamic Gene Expression Is Altered in Underweight but Obese Juvenile Male Sprague-Dawley Rats Fed a High-Energy Diet
J. Nutr., June 1, 2004; 134(6): 1369 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. H. Sliwowska, H. J. Billings, R. L. Goodman, L. M. Coolen, and M. N. Lehman
The Premammillary Hypothalamic Area of the Ewe: Anatomical Characterization of a Melatonin Target Area Mediating Seasonal Reproduction
Biol Reprod, June 1, 2004; 70(6): 1768 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Tups, C. Ellis, K. M. Moar, T. J. Logie, C. L. Adam, J. G. Mercer, and M. Klingenspor
Photoperiodic Regulation of Leptin Sensitivity in the Siberian Hamster, Phodopus sungorus, Is Reflected in Arcuate Nucleus SOCS-3 (Suppressor of Cytokine Signaling) Gene Expression
Endocrinology, March 1, 2004; 145(3): 1185 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
W. L. Peacock, E. Krol, K. M. Moar, J. S. McLaren, J. G. Mercer, and J. R. Speakman
Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole
J. Exp. Biol., January 1, 2004; 207(1): 165 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. Arens, K. M. Moar, S. Eiden, K. Weide, I. Schmidt, J. G. Mercer, E. Simon, and H.-W. Korf
Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice
Physiol Genomics, December 16, 2003; 16(1): 38 - 46.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Rousseau, Z. Atcha, F. R. A. Cagampang, P. Le Rouzic, J. A. Stirland, T. R. Ivanov, F. J. P. Ebling, M. Klingenspor, and A. S. I. Loudon
Photoperiodic Regulation of Leptin Resistance in the Seasonally Breeding Siberian Hamster (Phodopus sungorus)
Endocrinology, August 1, 2002; 143(8): 3083 - 3095.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. G. Mercer, K. M. Moar, T. J. Logie, P. A. Findlay, C. L. Adam, and P. J. Morgan
Seasonally Inappropriate Body Weight Induced by Food Restriction: Effect on Hypothalamic Gene Expression in Male Siberian Hamsters
Endocrinology, October 1, 2001; 142(10): 4173 - 4181.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Sorensen, C. L. Adam, P. A. Findlay, M. Marie, L. Thomas, M. T. Travers, and R. G. Vernon
Leptin secretion and hypothalamic neuropeptide and receptor gene expression in sheep
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1227 - R1235.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society