help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laping, N. J.
Right arrow Articles by Finch, C. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laping, N. J.
Right arrow Articles by Finch, C. E.

Endocrinology, Vol 135, 1928-1933, Copyright © 1994 by Endocrine Society

ARTICLES

Transcriptional control of glial fibrillary acidic protein and glutamine synthetase in vivo shows opposite responses to corticosterone in the hippocampus

NJ Laping, NR Nichols, JR Day, SA Johnson and CE Finch
Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles 90089-0191.

Transcriptional regulation of two astrocyte genes, glial fibrillary acidic protein (GFAP) and glutamine synthase (GS), by glucocorticoids was determined by nuclear run-on assay with hippocampal tissues from adult male F344 rats. Transcriptional responses of GFAP to corticosterone were slower than those observed for GS, but were more sensitive to changes in plasma corticosterone. The transcription of GFAP did not change 2 h after the injection of 10 mg corticosterone, but was reduced by 50% at 6 and 24 h. In contrast, corticosterone increased GS transcription at 2 and 6 h. Seven days after adrenalectomy, GFAP, but not GS, transcription was increased. Corticosterone replacement (200 micrograms/ml in the drinking water) suppressed GFAP, but did not increase GS transcription in adrenalectomized rats. Therefore, GFAP transcription is more sensitive to low physiological levels of corticosterone than transcription of GS. The slower response of GFAP than GS to corticosterone suggests that glucocorticoids may have indirect effects on GFAP expression that require additional transcriptional regulators besides the glucocorticoid receptor.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. Zschocke, N. Bayatti, A. M. Clement, H. Witan, M. Figiel, J. Engele, and C. Behl
Differential Promotion of Glutamate Transporter Expression and Function by Glucocorticoids in Astrocytes from Various Brain Regions
J. Biol. Chem., October 14, 2005; 280(41): 34924 - 34932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Chandrasekhar, W. W. Souba, and S. F. Abcouwer
Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase
Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L319 - L331.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Stone, Y. Song, C. P. Anderson, K. K. Krohn, C. E. Finch, and I. Rozovsky
Bidirectional Transcription Regulation of Glial Fibrillary Acidic Protein by Estradiol in Vivo and in Vitro
Endocrinology, July 1, 1998; 139(7): 3202 - 3209.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society