help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Urena, P.
Right arrow Articles by Segre, G. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Urena, P.
Right arrow Articles by Segre, G. V.

Endocrinology, Vol 133, 617-623, Copyright © 1993 by Endocrine Society

ARTICLES

Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues

P Urena, XF Kong, AB Abou-Samra, H Juppner, HM Kronenberg, JT Potts Jr and GV Segre
Endocrine Unit, Massachusetts General Hospital, Boston 02114.

PTH/PTH-related peptide (PTHrP) receptor mRNAs are widely distributed in rat tissues. PTH and PTHrP, a peptide responsible for hypercalcemia associated with cancers, bind equivalently to common receptors that initially were cloned from rat bone and opossum renal cell cDNA libraries. In this study we used rat PTH/PTHrP receptor cDNA to probe for receptor expression in different rat tissues by Northern blot analysis. PTH/PTHrP receptor transcripts are highly expressed in PTH target tissues, kidney and bone. Receptor transcripts, however, also are expressed in many other tissues, including aorta, adrenal gland, bladder, brain, cerebellum, breast, heart, ileum, liver, lung, skeletal muscle, ovary, placenta, skin, spleen, stomach, uterus, and testes. The major transcript in most tissues is 2.3-2.5 kilobases in size. At least two larger mRNAs are observed in kidney and liver, and smaller transcripts are found in kidney, skin, and testes. The most abundant testicular transcript is 1.4-1.5 kilobases in size, and it hybridizes with two different cDNA probes that encode portions of the receptor sequence from the putative fourth transmembrane domain to its C- terminal end. It does not hybridize, however, with a probe encoding the first 107 residues of the receptor sequence. Although, PTH/PTHrP receptor mRNAs are highly expressed in kidney and bone, classic PTH targets that are associated with calcium homeostasis, their wide tissue distribution suggests that PTH and/or PTHrP have other physiological roles, particularly in these other tissues. The mechanisms leading to tissue-specific expression of PTH/PTHrP receptor transcripts of different sizes and the functions of these mRNAs remain to be determined.


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
M.-M. Zaruba, B. C. Huber, S. Brunner, E. Deindl, R. David, R. Fischer, G. Assmann, N. Herbach, S. Grundmann, R. Wanke, et al.
Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival
Cardiovasc Res, March 1, 2008; 77(4): 722 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
G. Rashid, J. Bernheim, J. Green, and S. Benchetrit
Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways
Nephrol. Dial. Transplant., October 1, 2007; 22(10): 2831 - 2837.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Reppe, L. Stilgren, B. Abrahamsen, O. K. Olstad, F. Cero, K. Brixen, L. S. Nissen-Meyer, and K. M. Gautvik
Abnormal muscle and hematopoietic gene expression may be important for clinical morbidity in primary hyperparathyroidism
Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1465 - E1473.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Ross, P. Engel, Y. Abdallah, W. Kummer, and K. D. Schluter
Tuberoinfundibular Peptide of 39 Residues: A New Mediator of Cardiac Function via Nitric Oxide Production in the Rat Heart
Endocrinology, May 1, 2005; 146(5): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. M. Murray, L. G. Rao, P. Divieti, and F. R. Bringhurst
Parathyroid Hormone Secretion and Action: Evidence for Discrete Receptors for the Carboxyl-Terminal Region and Related Biological Actions of Carboxyl- Terminal Ligands
Endocr. Rev., February 1, 2005; 26(1): 78 - 113.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Lepourcelet, L. Tou, L. Cai, J.-i. Sawada, A. J. F. Lazar, J. N. Glickman, J. A. Williamson, A. D. Everett, M. Redston, E. A. Fox, et al.
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
Development, January 15, 2005; 132(2): 415 - 427.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Rotllant, P. M. Guerreiro, L. Anjos, B. Redruello, A. V. M. Canario, and D. M. Power
Stimulation of Cortisol Release by the N Terminus of Teleost Parathyroid Hormone-Related Protein in Interrenal Cells in Vitro
Endocrinology, January 1, 2005; 146(1): 71 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
P. Andersson, E. Rydberg, and R. Willenheimer
Primary hyperparathyroidism and heart disease -- a review
Eur. Heart J., October 2, 2004; 25(20): 1776 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Fritsch, V. Lindner, S. Welsch, T. Massfelder, M. Grima, S. Rothhut, M. Barthelmebs, and J.-J. Helwig
Intravenous Delivery of PTH/PTHrP Type 1 Receptor cDNA to Rats Decreases Heart Rate, Blood Pressure, Renal Tone, Renin Angiotensin System, and Stress-Induced Cardiovascular Responses
J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2588 - 2600.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Mitchell, T. C. Ting, S. Wong, B.F. Mitchell, and S. J. Lye
Parathyroid Hormone-Related Protein Treatment of Pregnant Rats Delays the Increase in Connexin 43 and Oxytocin Receptor Expression in the Myometrium
Biol Reprod, August 1, 2003; 69(2): 556 - 562.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. K. Chan, R. A. Deckelbaum, I. Bolivar, D. Goltzman, and A. C. Karaplis
PTHrP Inhibits Adipocyte Differentiation by Down-Regulating PPAR{gamma} Activity via a MAPK-Dependent Pathway
Endocrinology, November 1, 2001; 142(11): 4900 - 4909.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. A. W. Tawfeek, J. Che, F. Qian, and A. B. Abou-Samra
Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation
Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E545 - E557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. A. Mitnick, A. Grey, U. Masiukiewicz, M. Bartkiewicz, L. Rios-Velez, S. Friedman, L. Xu, M. C. Horowitz, and K. Insogna
Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E405 - E412.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Mazzocchi, F. Aragona, L. K. Malendowicz, and G. G. Nussdorfer
PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells
Am J Physiol Endocrinol Metab, February 1, 2001; 280(2): E209 - E213.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. D. Short and C. W. Taylor
Parathyroid Hormone Controls the Size of the Intracellular Ca2+ Stores Available to Receptors Linked to Inositol Trisphosphate Formation
J. Biol. Chem., January 21, 2000; 275(3): 1807 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. R. Miles, J. P. Sluka, R. F. Santerre, L. V. Hale, L. Bloem, G. Boguslawski, K. Thirunavukkarasu, J. M. Hock, and J. E. Onyia
Dynamic Regulation of RGS2 in Bone: Potential New Insights into Parathyroid Hormone Signaling Mechanisms
Endocrinology, January 1, 2000; 141(1): 28 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Mannstadt, H. Juppner, and T. J. Gardella
Receptors for PTH and PTHrP: their biological importance and functional properties
Am J Physiol Renal Physiol, November 1, 1999; 277(5): F665 - F675.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Grey, M.-A. Mitnick, U. Masiukiewicz, B.-H. Sun, S. Rudikoff, R. L. Jilka, S. C. Manolagas, and K. Insogna
A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo
Endocrinology, October 1, 1999; 140(10): 4683 - 4690.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
V. Behar, A. Bisello, M. Rosenblatt, and M. Chorev
Direct Identification of Two Contact Sites for Parathyroid Hormone (PTH) in the Novel PTH-2 Receptor using Photoaffinity Cross-Linking
Endocrinology, September 1, 1999; 140(9): 4251 - 4261.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
M. Karperien, H. Farih-Sips, J. A.A. Hendriks, B. Lanske, S. E. Papapoulos, A.-B. Abou-Samra, C. W.G.M. Löwik, and L. H.K. Defize
Identification of a Retinoic Acid-Inducible Element in the Murine PTH/PTHrP (Parathyroid Hormone/Parathyroid Hormone-Related Peptide) Receptor Gene
Mol. Endocrinol., July 1, 1999; 13(7): 1183 - 1196.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. B. Usdin, J. Hilton, T. Vertesi, G. Harta, G. Segre, and E. Mezey
Distribution of the Parathyroid Hormone 2 Receptor in Rat: Immunolocalization Reveals Expression by Several Endocrine Cells
Endocrinology, July 1, 1999; 140(7): 3363 - 3371.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. Lanske, P. Divieti, C. S. Kovacs, A. Pirro, W. J. Landis, S. M. Krane, F. R. Bringhurst, and H. M. Kronenberg
The Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mediates Actions of Both Ligands in Murine Bone
Endocrinology, December 1, 1998; 139(12): 5194 - 5204.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Bergwitz, P. Klein, H. Kohno, S. A. Forman, K. Lee, D. Rubin, and H. Juppner
Identification, Functional Characterization, and Developmental Expression of Two Nonallelic Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Isoforms in Xenopus laevis (Daudin)
Endocrinology, February 1, 1998; 139(2): 723 - 732.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Noda, T. Katoh, K. Kurokawa, and Y. Takuwa
Increased Expression of Parathyroid Hormone–Related Peptide Gene in Blood Vessels of Spontaneously Hypertensive Rats
Hypertension, November 1, 1997; 30(5): 1284 - 1288.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. h. Sun, M. Mitnick, C. Eielson, G. Q. Yao, I. Paliwal, and K. Insogna
Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy
Endocrinology, September 1, 1997; 138(9): 3918 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. L. Funk, A. H. Moser, C. Grunfeld, and K. R. Feingold
Parathyroid Hormone-Related Protein Is Induced in the Adult Liver during Endotoxemia and Stimulates the Hepatic Acute Phase Response
Endocrinology, July 1, 1997; 138(7): 2665 - 2673.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ono, K. Inokuchi, A. Ogura, Y. Ikawa, Y. Kudo, and S. Kawashima
Activity-dependent Expression of Parathyroid Hormone-related Protein (PTHrP) in Rat Cerebellar Granule Neurons. REQUIREMENT OF PTHrP FOR THE ACTIVITY-DEPENDENT SURVIVAL OF GRANULE NEURONS
J. Biol. Chem., May 30, 1997; 272(22): 14404 - 14411.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Yamamoto, I. Morimoto, N. Yanagihara, K. Zeki, T. Fujihira, F. Izumi, H. Yamashita, and S. Eto
Parathyroid Hormone-Related Peptide-(1-34) [PTHrP- (1-34)] Induces Vasopressin Release from the Rat Supraoptic Nucleus in Vitro through a Novel Receptor Distinct from a Type I or Type II PTH/PTHrP Receptor
Endocrinology, May 1, 1997; 138(5): 2066 - 2072.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Ray and S. Melmed
Pituitary Cytokine and Growth Factor Expression and Action
Endocr. Rev., April 1, 1997; 18(2): 206 - 228.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
H. Joun, B. Lanske, M. Karperien, F. Qian, L. Defize, and A. Abou-Samra
Tissue-Specific Transcription Start Sites and Alternative Splicing of the Parathyroid Hormone (PTH)/PTH-Related Peptide (PTHrP) Receptor Gene: A New PTH/PTHrP Receptor Splice Variant that Lacks the Signal Peptide
Endocrinology, April 1, 1997; 138(4): 1742 - 1749.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Iida-Klein, J. Guo, M. Takemura, M. T. Drake, J. T. Potts Jr., A. Abou-Samra, F. R. Bringhurst, and G. V. Segre
Mutations in the Second Cytoplasmic Loop of the Rat Parathyroid Hormone (PTH)/PTH-related Protein Receptor Result in Selective Loss of PTH-stimulated Phospholipase C Activity
J. Biol. Chem., March 14, 1997; 272(11): 6882 - 6889.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Amizuka, H. S. Lee, M. Y. Kwan, A. Arazani, H. Warshawsky, G. N. Hendy, H. Ozawa, J. H. White, and D. Goltzman
Cell-Specific Expression of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene in Kidney from Kidney-Specific and Ubiquitous Promoters
Endocrinology, January 1, 1997; 138(1): 469 - 481.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. Schipani, C.B. Langman, A.M. Parfitt, G.S. Jensen, S. Kikuchi, S.W. Kooh, W.G. Cole, and H. Juppner
Constitutively Activated Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide in Jansen's Metaphyseal Chondrodysplasia
N. Engl. J. Med., September 5, 1996; 335(10): 708 - 714.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Azarani, D. Goltzman, and J. Orlowski
Structurally Diverse N-terminal Peptides of Parathyroid Hormone (PTH) and PTH-related Peptide (PTHRP) Inhibit the Na+/H+ Exchanger NHE3 Isoform by Binding to the PTH/PTHRP Receptor Type I and Activating Distinct Signaling Pathways
J. Biol. Chem., June 21, 1996; 271(25): 14931 - 14936.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S.-i. Ozeki, A. Ohtsuru, S. Seto, S. Takeshita, H. Yano, T. Nakayama, M. Ito, T. Yokota, M. Nobuyoshi, G. V. Segre, et al.
Evidence That Implicates the Parathyroid Hormone–Related Peptide in Vascular Stenosis : Increased Gene Expression in the Intima of Injured Rat Carotid Arteries and Human Restenotic Coronary Lesions
Arterioscler. Thromb. Vasc. Biol., April 1, 1996; 16(4): 565 - 575.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
T. B. Usdin, C. Gruber, and T. I. Bonner
Identification and Functional Expression of a Receptor Selectively Recognizing Parathyroid Hormone, the PTH2 Receptor
J. Biol. Chem., June 30, 1995; 270(26): 15455 - 15458.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Wysolmerski, J. McCaughern-Carucci, A. Daifotis, A. Broadus, and W. Philbrick
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development
Development, January 11, 1995; 121(11): 3539 - 3547.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1993 by The Endocrine Society