help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Myers, M. G.
Right arrow Articles by White, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Myers, M. G., Jr
Right arrow Articles by White, M. F.

Endocrinology, Vol 132, 1421-1430, Copyright © 1993 by Endocrine Society

ARTICLES

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

MG Myers Jr, XJ Sun, B Cheatham, BR Jachna, EM Glasheen, JM Backer and MF White
Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215.

IRS-1 is a unique cytosolic protein that becomes tyrosine phosphorylated during insulin stimulation of intact cells and immediately associates with the phosphatidylinositol 3'-kinase (PtdIns 3'-kinase). The insulin-like growth factor-I (IGF-I) receptor also mediated the tyrosine phosphorylation of IRS-1 and increased the amount of PtdIns 3'-kinase activity bound to IRS-1 in Chinese hamster ovary cells. Purified insulin receptor and IGF-I receptor phosphorylated recombinant baculovirus-produced IRS-1 on similar sites in vitro, and phosphorylated baculovirus-produced IRS-1 bound PtdIns 3'-kinase activity from lysates of quiescent cells. Treatment of cells with IGF-I activated the PtdIns 3'-kinase, suggesting that IGF-I activates the PtdIns 3'-kinase through IRS-1 binding to p85 in a manner similar to insulin. Chinese hamster ovary cells overexpressing IRS-1 demonstrated increased tyrosine phosphorylation of IRS-1, and more PtdIns 3'-kinase activity associated with IRS-1 in these cells. These data demonstrate that IRS-1 is a common element for signal transmission by the IGF-I and insulin receptors.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. Radhakrishnan, L. A. Maile, Y. Ling, L. M. Graves, and D. R. Clemmons
Insulin-like Growth Factor-I Stimulates Shc-dependent Phosphatidylinositol 3-Kinase Activation via Grb2-associated p85 in Vascular Smooth Muscle Cells
J. Biol. Chem., June 13, 2008; 283(24): 16320 - 16331.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. S. Metlakunta, M. Sahu, and A. Sahu
Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice
Endocrinology, March 1, 2008; 149(3): 1121 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Salani, L. Briatore, S. Garibaldi, R. Cordera, and D. Maggi
Caveolin-1 Down-Regulation Inhibits Insulin-Like Growth Factor-I Receptor Signal Transduction in H9C2 Rat Cardiomyoblasts
Endocrinology, February 1, 2008; 149(2): 461 - 465.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. G. Kang, A. L. Brown, and J. H. Chung
Oxygen Tension Regulates the Stability of Insulin Receptor Substrate-1 (IRS-1) through Caspase-mediated Cleavage
J. Biol. Chem., March 2, 2007; 282(9): 6090 - 6097.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Fornoni, S. A. Rosenzweig, O. Lenz, A. Rivera, G. E. Striker, and S. J. Elliot
Low Insulin-Like Growth Factor Binding Protein-2 Expression Is Responsible for Increased Insulin Receptor Substrate-1 Phosphorylation in Mesangial Cells from Mice Susceptible to Glomerulosclerosis
Endocrinology, July 1, 2006; 147(7): 3547 - 3554.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Kwon, Y. Ling, L. A. Maile, J. Badley-Clark, and D. R. Clemmons
Recruitment of the Tyrosine Phosphatase Src Homology 2 Domain Tyrosine Phosphatase-2 to the p85 Subunit of Phosphatidylinositol-3 (PI-3) Kinase Is Required for Insulin-Like Growth Factor-I-Dependent PI-3 Kinase Activation in Smooth Muscle Cells
Endocrinology, March 1, 2006; 147(3): 1458 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. Y. Irie, R. V. Pearline, D. Grueneberg, M. Hsia, P. Ravichandran, N. Kothari, S. Natesan, and J. S. Brugge
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
J. Cell Biol., December 19, 2005; 171(6): 1023 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Otani, R. N. Kulkarni, A. C. Baldwin, J. Krutzfeldt, K. Ueki, M. Stoffel, C. R. Kahn, and K. S. Polonsky
Reduced {beta}-cell mass and altered glucose sensing impair insulin-secretory function in {beta}IRKO mice
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E41 - E49.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
S. Poser, S. Impey, Z. Xia, and D. R. Storm
Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP
J. Neurosci., June 1, 2003; 23(11): 4420 - 4427.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. R. Clemmons and L. A. Maile
Minireview: Integral Membrane Proteins that Function Coordinately with the Insulin-Like Growth Factor I Receptor to Regulate Intracellular Signaling
Endocrinology, May 1, 2003; 144(5): 1664 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Podar, Y.-T. Tai, C. E. Cole, T. Hideshima, M. Sattler, A. Hamblin, N. Mitsiades, R. L. Schlossman, F. E. Davies, G. J. Morgan, et al.
Essential Role of Caveolae in Interleukin-6- and Insulin-like Growth Factor I-triggered Akt-1-mediated Survival of Multiple Myeloma Cells
J. Biol. Chem., February 14, 2003; 278(8): 5794 - 5801.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Garcia-Ocana, K. K. Takane, V. T. Reddy, J.-C. Lopez-Talavera, R. C. Vasavada, and A. F. Stewart
Adenovirus-mediated Hepatocyte Growth Factor Expression in Mouse Islets Improves Pancreatic Islet Transplant Performance and Reduces Beta Cell Death
J. Biol. Chem., January 3, 2003; 278(1): 343 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Chang, Y. Li, M. F. White, J. A. Fletcher, and S. Xiao
Constitutive Activation of Insulin Receptor Substrate 1 Is a Frequent Event in Human Tumors: Therapeutic Implications
Cancer Res., November 1, 2002; 62(21): 6035 - 6038.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
W.-H. Zheng, S. Kar, and R. Quirion
Insulin-Like Growth Factor-1-Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3-Kinase/Akt Kinase and Role of This Pathway in Insulin-Like Growth Factor-1-Induced Survival of Cultured Hippocampal Neurons
Mol. Pharmacol., August 1, 2002; 62(2): 225 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Sciacchitano, A. Orecchio, L. Lavra, S. Misiti, A. Giacchini, M. Zani, D. Danese, A. Gurtner, S. Soddu, U. Di Mario, et al.
Cloning of the Mouse Insulin Receptor Substrate-3 (mIRS-3) Promoter, and Its Regulation by p53
Mol. Endocrinol., July 1, 2002; 16(7): 1577 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Pratipanawatr, W. Pratipanawatr, C. Rosen, R. Berria, M. Bajaj, K. Cusi, L. Mandarino, S. Kashyap, R. Belfort, and R. A. DeFronzo
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects
Am J Physiol Endocrinol Metab, June 1, 2002; 282(6): E1360 - E1368.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Luis Del Valle, S. Enam, A. Lassak, J. Y. Wang, S. Croul, K. Khalili, and K. Reiss
Insulin-like Growth Factor I Receptor Activity in Human Medulloblastomas
Clin. Cancer Res., June 1, 2002; 8(6): 1822 - 1830.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Murata, Y. Okimura, K. Iida, M. Matsumoto, H. Sowa, H. Kaji, M. Kojima, K. Kangawa, and K. Chihara
Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells
J. Biol. Chem., February 8, 2002; 277(7): 5667 - 5674.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
I. Tack, S. J. Elliot, M. Potier, A. Rivera, G. E. Striker, and L. J. Striker
Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice
Diabetes, January 1, 2002; 51(1): 182 - 188.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Sasaoka, M. Ishiki, T. Wada, H. Hori, H. Hirai, T. Haruta, H. Ishihara, and M. Kobayashi
Tyrosine Phosphorylation-Dependent and -Independent Role of Shc in the Regulation of IGF-1-Induced Mitogenesis and Glycogen Synthesis
Endocrinology, December 1, 2001; 142(12): 5226 - 5235.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Dupont, J. Khan, B.-H. Qu, P. Metzler, L. Helman, and D. LeRoith
Insulin and IGF-1 Induce Different Patterns of Gene Expression in Mouse Fibroblast NIH-3T3 Cells: Identification by cDNA Microarray Analysis
Endocrinology, November 1, 2001; 142(11): 4969 - 4975.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. J. Kim, B.-C. Park, Y. Kido, and D. Accili
Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes
Endocrinology, August 1, 2001; 142(8): 3354 - 3360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Shefi-Friedman, E. Wertheimer, S. Shen, A. Bak, D. Accili, and S. R. Sampson
Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice
Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E16 - E24.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Miki, T. Yamauchi, R. Suzuki, K. Komeda, A. Tsuchida, N. Kubota, Y. Terauchi, J. Kamon, Y. Kaburagi, J. Matsui, et al.
Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation
Mol. Cell. Biol., April 1, 2001; 21(7): 2521 - 2532.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. L. Hadsell, T. Alexeenko, Y. Klemintidis, D. Torres, and A. V. Lee
Inability of Overexpressed des(1-3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules
Endocrinology, April 1, 2001; 142(4): 1479 - 1488.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
C. M. CHENG, M. COHEN, J. WANG, and C. A. BONDY
Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
FASEB J, April 1, 2001; 15(6): 907 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L.-P. Weng, W. M. Smith, J. L. Brown, and C. Eng
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Hum. Mol. Genet., March 1, 2001; 10(6): 605 - 616.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Navarro and R. Baserga
Limited Redundancy of Survival Signals from the Type 1 Insulin-Like Growth Factor Receptor
Endocrinology, March 1, 2001; 142(3): 1073 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N.-L. Ge and S. Rudikoff
Insulin-like growth factor I is a dual effector of multiple myeloma cell growth
Blood, October 15, 2000; 96(8): 2856 - 2861.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Cusi and R. DeFronzo
Recombinant Human Insulin-Like Growth Factor I Treatment for 1 Week Improves Metabolic Control in Type 2 Diabetes by Ameliorating Hepatic and Muscle Insulin Resistance
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3077 - 3084.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
R.-S. Schmid, W. M. Pruitt, and P. F. Maness
A MAP Kinase-Signaling Pathway Mediates Neurite Outgrowth on L1 and Requires Src-Dependent Endocytosis
J. Neurosci., June 1, 2000; 20(11): 4177 - 4188.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-H. Zheng, S. Kar, and R. Quirion
Stimulation of Protein Kinase C Modulates Insulin-like Growth Factor-1-induced Akt Activation in PC12 Cells
J. Biol. Chem., April 28, 2000; 275(18): 13377 - 13385.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Morrione, G. Romano, M. Navarro, K. Reiss, B. Valentinis, M. Dews, E. Eves, M. R. Rosner, and R. Baserga
Insulin-like Growth Factor I Receptor Signaling in Differentiation of Neuronal H19-7 Cells
Cancer Res., April 1, 2000; 60(8): 2263 - 2272.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. N. Winnay, J. C. Bruning, D. J. Burks, and C. R. Kahn
Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts
J. Biol. Chem., March 31, 2000; 275(14): 10545 - 10550.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Ueno, E. Kondo, R. Yamamoto-Honda, K. Tobe, T. Nakamoto, K. Sasaki, K. Mitani, A. Furusaka, T. Tanaka, Y. Tsujimoto, et al.
Association of Insulin Receptor Substrate Proteins with Bcl-2 and Their Effects on Its Phosphorylation and Antiapoptotic Function
Mol. Biol. Cell, February 1, 2000; 11(2): 735 - 746.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
B. Urso, D. L. Cope, H. E. Kalloo-Hosein, A. C. Hayward, J. P. Whitehead, S. O'Rahilly, and K. Siddle
Differences in Signaling Properties of the Cytoplasmic Domains of the Insulin Receptor and Insulin-like Growth Factor Receptor in 3T3-L1 Adipocytes
J. Biol. Chem., October 22, 1999; 274(43): 30864 - 30873.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Peruzzi, M. Prisco, M. Dews, P. Salomoni, E. Grassilli, G. Romano, B. Calabretta, and R. Baserga
Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis
Mol. Cell. Biol., October 1, 1999; 19(10): 7203 - 7215.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. E. Levitt Katz, R. J. Ferry Jr., C. A. Stanley, P. F. Collett-Solberg, L. Baker, and P. Cohen
Suppression of Insulin Oversecretion by Subcutaneous Recombinant Human Insulin-Like Growth Factor I in Children with Congenital Hyperinsulinism Due to Defective {beta}-Cell Sulfonylurea Receptor
J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3117 - 3124.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Auclair, C. Vigouroux, C. Desbois-Mouthon, J. Deibener, P. Kaminski, O. Lascols, G. Cherqui, J. Capeau, and M. Caron
Antiinsulin Receptor Autoantibodies Induce Insulin Receptors to Constitutively Associate with Insulin Receptor Substrate-1 and -2 and Cause Severe Cell Resistance to Both Insulin and Insulin-Like Growth Factor I
J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3197 - 3206.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. F. di Mari, R. Davis, and R. L. Safirstein
MAPK activation determines renal epithelial cell survival during oxidative injury
Am J Physiol Renal Physiol, August 1, 1999; 277(2): F195 - F203.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. L. Swantek and R. Baserga
Prolonged Activation of ERK2 by Epidermal Growth Factor and Other Growth Factors Requires a Functional Insulin-Like Growth Factor 1 Receptor
Endocrinology, July 1, 1999; 140(7): 3163 - 3169.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
D. Coppola, B. Saunders, L. Fu, W. Mao, and S. V. Nicosia
The Insulin-like Growth Factor 1 Receptor Induces Transformation and Tumorigenicity of Ovarian Mesothelial Cells and Down-Regulates Their Fas-Receptor Expression
Cancer Res., July 1, 1999; 59(13): 3264 - 3270.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Minshall, S. Arkins, R. Dantzer, G. G. Freund, and K. W. Kelley
Phosphatidylinositol 3'-Kinase, But Not S6-Kinase, Is Required for Insulin-Like Growth Factor-I and IL-4 To Maintain Expression of Bcl-2 and Promote Survival of Myeloid Progenitors
J. Immunol., April 15, 1999; 162(8): 4542 - 4549.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Kawane and N. Horiuchi
Insulin-Like Growth Factor I Suppresses Parathyroid Hormone (PTH)/PTH-Related Protein Receptor Expression via a Mitogen-Activated Protein Kinase Pathway in UMR-106 Osteoblast-Like Cells
Endocrinology, February 1, 1999; 140(2): 871 - 879.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
P. Lebrun, I. Mothe-Satney, L. Delahaye, E. Van Obberghen, and V. Baron
Insulin Receptor Substrate-1 as a Signaling Molecule for Focal Adhesion Kinase pp125FAK and pp60src
J. Biol. Chem., November 27, 1998; 273(48): 32244 - 32253.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.'i. Hayashi, H. Saga, Y. Chimori, K. Kimura, Y. Yamanaka, and K. Sobue
Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase
J. Biol. Chem., October 30, 1998; 273(44): 28860 - 28867.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Okubo, V. A. Blakesley, B. Stannard, S. Gutkind, and D. Le Roith
Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase
J. Biol. Chem., October 2, 1998; 273(40): 25961 - 25966.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Zheng and D. R. Clemmons
Blocking ligand occupancy of the alpha Vbeta 3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells
PNAS, September 15, 1998; 95(19): 11217 - 11222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. F. Kuemmerle and T. L. Bushman
IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways
Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G151 - G158.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. G. Richards, M. P. Walker, J. Sebastian, and R. P. DiAugustine
Insulin-like Growth Factor-1 (IGF-1) Receptor-Insulin Receptor Substrate Complexes in the Uterus. ALTERED SIGNALING RESPONSE TO ESTRADIOL IN THE IGF-1m/m MOUSE
J. Biol. Chem., May 8, 1998; 273(19): 11962 - 11969.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. C. Chow, G. Condorelli, and R. J. Smith
Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway
J. Biol. Chem., February 20, 1998; 273(8): 4672 - 4680.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Morrione, B. Valentinis, M. Resnicoff, S.-q. Xu, and R. Baserga
The Role of mGrb10alpha in Insulin-like Growth Factor I-mediated Growth
J. Biol. Chem., October 17, 1997; 272(42): 26382 - 26387.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K.-C. Leung, M. J. Waters, I. Markus, W. R. Baumbach, and K. K. Y. Ho
Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: A novel mechanism of growth hormone receptor regulation
PNAS, October 14, 1997; 94(21): 11381 - 11386.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Burfoot, N. C. Rogers, D. Watling, J. M. Smith, S. Pons, G. Paonessaw, S. Pellegrini, M. F. White, and I. M. Kerr
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons
J. Biol. Chem., September 26, 1997; 272(39): 24183 - 24190.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. E. Kalloo-Hosein, J. P. Whitehead, M. Soos, J. M. Tavare, K. Siddle, and S. O'Rahilly
Differential Signaling to Glycogen Synthesis by the Intracellular Domain of the Insulin versus the Insulin-like Growth Factor-1 Receptor. EVIDENCE FROM STUDIES OF TrkC-CHIMERAS
J. Biol. Chem., September 26, 1997; 272(39): 24325 - 24332.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Foncea, M. Andersson, A. Ketterman, V. Blakesley, M. Sapag-Hagar, P. H. Sugden, D. LeRoith, and S. Lavandero
Insulin-like Growth Factor-I Rapidly Activates Multiple Signal Transduction Pathways in Cultured Rat Cardiac Myocytes
J. Biol. Chem., August 1, 1997; 272(31): 19115 - 19124.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. C. Haddad and C. A. Conover
Insulin and Interleukin-4 Induce Desensitization to the Mitogenic Effects of Insulin-like Growth Factor-I. PIVOTAL ROLE FOR INSULIN RECEPTOR SUBSTRATE-2
J. Biol. Chem., August 1, 1997; 272(31): 19525 - 19531.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Sawka-Verhelle, V. Baron, I. Mothe, C. Filloux, M. F. White, and E. Van Obberghen
Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor
J. Biol. Chem., June 27, 1997; 272(26): 16414 - 16420.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Morrione, B. Valentinis, S.-q. Xu, G. Yumet, A. Louvi, A. Efstratiadis, and R. Baserga
Insulin-like growth factor II stimulates cell proliferation through the insulin receptor
PNAS, April 15, 1997; 94(8): 3777 - 3782.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. V. Bhat, T. M. Engber, Y. Zhu, M. S. Miller, and P. C. Contreras
Identification of Insulin-Like Growth Factor Binding Protein-2 as a Biochemical Surrogate Marker for the in Vivo Effects of Recombinant Human Insulin-Like Growth Factor-1 in Mice
J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 522 - 530.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. A. Coolican, D. S. Samuel, D. Z. Ewton, F. J. McWade, and J. R. Florini
The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways
J. Biol. Chem., March 7, 1997; 272(10): 6653 - 6662.
[Abstract] [Full Text] [PDF]

Home page
<