Endocrinology, Vol 129, 2219-2224, Copyright © 1991 by Endocrine Society

ARTICLES

Enhanced insulin secretory response to acetylcholine by perifused pancreas of 5-day-old preobese Zucker rats

N Atef, C Brule, MT Bihoreau, A Ktorza, L Picon and L Penicaud
Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Universite Paris VII, France.

The insulin secretion rate in response to different secretagogues and neurotransmittors was studied in perifused pancreas of 5-day-old lean (Fa/Fa) and preobese (fa/fa) Zucker rats. Glucose (16.6 mM) alone or in combination with 20 mM arginine or 5 mM theophylline induced a net stimulation of insulin secretion. This effect was similar in the two groups. By contrast, the stimulatory effect of acetylcholine on glucose- induced insulin secretion was significantly higher in preobese pups than in lean rats. There was also a tendency toward a higher inhibitory effect of norepinephrine on insulin secretion in preobese than in lean rats, but this difference did not reach statistical significance. Together these results demonstrate a normal insulin secretion in response to nutrient secretagogues in preobese fa/fa rats but an enhanced effect of acetylcholine. This latter effect may be related to the changes in the autonomic nervous system activity, which is usually described in obese fa/fa rats.

This article has been cited by other articles:

				K. L. Teff and R. R. Townsend Prolonged Mild Hyperglycemia Induces Vagally Mediated Compensatory Increase in C-Peptide Secretion in Humans J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5606 - 5613. [Abstract] [Full Text] [PDF]

				P. Gilon and J.-C. Henquin Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic {beta}-Cell Function Endocr. Rev., October 1, 2001; 22(5): 565 - 604. [Abstract] [Full Text] [PDF]