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Endocrinology, Vol 129, 559-561, Copyright © 1991 by Endocrine Society

ARTICLES

ANF mRNA is detected by the polymerase chain reaction technique in the chorioidea and bodies but not in the retina of the rat eye

L Gaspar, R Fernandez-Durango, NG Seidah, M Chretien and J Gutkowska
J. A. DeSeve Laboratory of Molecular, Neuroendocrinology, Clinical Research Institute of Montreal, Quebec, Canada.

Specific proANF mRNA was demonstrated by the polymerase chain reaction (PCR) technique in ciliary body and chorioidea tissue extracts but not in the retina of the rat eye. However, immunoreactive (IR) ANF was detected in all of these tissues by a specific and sensitive radioimmunoassay (RIA). Since ANF seems to be involved in the maintenance of intraocular pressure, the regulation of ANF gene expression in these distinct eye tissues could be an important factor in the pathogenesis of glaucoma.


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S. Z. Kim, H. S. Kim, K. S. Lee, S. J. Lee, K. H. Seul, G. Y. Koh, K. W. Cho, and S. H. Kim
Coexistence of C-Type Natriuretic Peptide and Atrial Natriuretic Peptide Systems in the Bovine Cornea
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2671 - 2677.
[Abstract] [Full Text]


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