help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horlick, K. R.
Right arrow Articles by Nick, H. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horlick, K. R.
Right arrow Articles by Nick, H. S.

Endocrinology, Vol 128, 1574-1579, Copyright © 1991 by Endocrine Society

ARTICLES

Annexin-I regulation in response to suckling and rat mammary cell differentiation

KR Horlick, M Ganjianpour, SC Frost and HS Nick
Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville 32610.

Expression of annexin-I was investigated in the rat mammary gland during pregnancy, lactation, and involution. Both the mRNA and protein were very abundant in the mature virgin gland, but declined significantly by midpregnancy. In the lactating gland, little or no annexin-I was detected. After weaning, mRNA and protein levels increased dramatically, corresponding to glandular involution. We also show that premature removal of the suckling stimulus caused a rapid increase in mRNA expression, but that translation of message was delayed, possibly until the gland was irreversibly committed to involution. Since high levels of annexin-I are associated with the quiescent epithelial cell, annexin-I may play an important role in blocking differentiation of the mammary gland.


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
T. Stein, K. N. Price, J. S. Morris, V. J. Heath, R. K. Ferrier, A. K. Bell, M.-A. Pringle, R. Villadsen, O. W. Petersen, G. Sauter, et al.
Annexin A8 Is Up-Regulated During Mouse Mammary Gland Involution and Predicts Poor Survival in Breast Cancer
Clin. Cancer Res., October 1, 2005; 11(19): 6872 - 6879.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S.-H. Liu, C.-Y. Lin, S.-Y. Peng, Y.-M. Jeng, H.-W. Pan, P.-L. Lai, C.-L. Liu, and H.-C. Hsu
Down-Regulation of Annexin A10 in Hepatocellular Carcinoma Is Associated with Vascular Invasion, Early Recurrence, and Poor Prognosis in Synergy with p53 Mutation
Am. J. Pathol., May 1, 2002; 160(5): 1831 - 1837.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society