Endocrinology, Vol 125, 1385-1388, Copyright © 1989 by Endocrine Society

ARTICLES

Loss of androgenic induction of alpha 2u-globulin gene family in the liver of NIH black rats

B Chatterjee, WF Demyan, CS Song, BD Garg and AK Roy
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

Unlike all known strains of rat, the androgen-inducible alpha 2u- globulin gene family is totally silent in the liver of NIH black (NB) rats. No endocrinological or reproductive abnormalities are apparent, and the mRNA for the androgen-repressible hepatic protein SMP-2 is normally regulated in these animals. Furthermore, immunoblot analysis shows a normal level of the male-specific cytoplasmic androgen-binding protein. Cross-breeding of the NB male and Sprague-Dawley female shows that the hybrid male in the F-1 generation regains the androgen- dependent expression of alpha 2u-globulin in the liver. These results along with the observation of high constitutive level of alpha 2u- globulin mRNA in the preputial gland of NB rats indicate a tissue- and gene-specific regulatory defect which prevents androgenic induction of alpha 2u-globulin in the liver.

This article has been cited by other articles:

				K. Takaba, K. Saeki, K. Suzuki, H. Wanibuchi, and S. Fukushima Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate Carcinogenesis, April 1, 2000; 21(4): 691 - 700. [Abstract] [Full Text] [PDF]