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Endocrinology, Vol 124, 3134-3136, Copyright © 1989 by Endocrine Society

ARTICLES

Ontogeny of peptidylglycine alpha-amidating monooxygenase activity in rapidly mineralizing bone from neonatal mouse

RS Birnbaum, GA Howard and BA Roos
Geriatric Research, Education, and Clinical Center, VA Medical Center, Tacoma, WA 98493.

Peptidylglycine alpha-amidating monooxygenase is hormonally, developmentally, and nutritionally regulated. In several tissues concomitant changes in enzyme activity and the level of expression of a known amidated peptide have been demonstrated. We report that neonatal mouse calvarium, a rapidly mineralizing bone, has detectable amidation enzyme activity. The level of activity varied 3-10-fold during the first 9 d of life. Production of one or more amidated peptides by bone may be coordinately regulated.




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Copyright © 1989 by The Endocrine Society