Endocrinology, Vol 123, 1690-1692, Copyright © 1988 by Endocrine Society

ARTICLES

Genetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth

HT Blair, SN McCutcheon, DD Mackenzie, JE Ormsby, RA Siddiqui, BH Breier and PD Gluckman
Department of Animal Science, Massey University, Palmerston North, New Zealand.

Substantial responses in the 6-week and mature body-weights of mice occurred after 7 generations of selection for or against plasma levels of Insulin-like Growth Factor-1 (IGF-1). Plasma levels of IGF-1 were also significantly different after 7 generations of selection (high line = 85 +/- 2 ng/ml, low line = 58 +/- 2 ng/ml). The average 6-week weight in the line selected for high plasma IGF-1 was 22.5 +/- .2 g compared with 18.5 +/- .2 g in the low plasma IGF-1 line, after 7 generations of selection. The difference between lines was maintained at 20 weeks of age. These data provide further evidence for the roles of IGF-1 in the regulation of somatic growth and as a mediator of a genetic component of growth.

This article has been cited by other articles:

				D. Le Roith, C. Bondy, S. Yakar, J.-L. Liu, and A. Butler The Somatomedin Hypothesis: 2001 Endocr. Rev., February 1, 2001; 22(1): 53 - 74. [Abstract] [Full Text]

				K. D. Laugero and G. P. Moberg Energetic response to repeated restraint stress in rapidly growing mice Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E33 - E43. [Abstract] [Full Text] [PDF]