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Endocrinology, Vol 123, 227-229, Copyright © 1988 by Endocrine Society

ARTICLES

Localization of pancreastatin immunoreactivity in porcine endocrine cells

M Ravazzola, S Efendic, CG Ostenson, K Tatemoto, JC Hutton and L Orci
Institute of Histology and Embryology, University of Geneva Medical School, Switzerland.

Pancreastatin is a peptide isolated from the porcine pancreas and shown to inhibit insulin release. We have studied the immunocytochemical distribution of pancreastatin in three porcine endocrine tissues: pancreas, gut, and adenohypophysis. Pancreastatin-specific immunoreactivity was found in all three locations and distributed to numerous cells. In the pancreas, we performed the alternate labeling of consecutive thick (immunofluorescence) or thin (protein A-gold) sections and we observed that pancreastatin colocalizes to secretory granules of insulin and somatostatin-containing cells. The relationship of pancreastatin to chromogranin A is discussed.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society