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Endocrinology, Vol 122, 2554-2557, Copyright © 1988 by Endocrine Society

ARTICLES

The lipolytic activity of low concentrations of insulin-like growth factors in ovine adipose tissue

KJ Lewis, PC Molan, JJ Bass and PD Gluckman
Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.

Insulin-like growth factor I (IGF-I) at concentrations of 40 ng/ml is lipogenic in ovine adipose tissue slices in vitro. Neither human IGF-II (hIGF-II) or rat IGF-II (rIGF-II) [multiplication-stimulating activity (MSA)] is lipogenic at similar concentrations. However, when present at lower concentrations recombinant human IGF-I (rhIGF-I) (400 pg/ml), hIGF-II (0.4 pg/ml), and MSA (40 pg/ml) were lipolytic. As IGF-II appeared more potent than IGF-I in promoting lipolysis, this effect may be mediated via the type 2 IGF receptor. The lipolytic effect of GH may be partly due to the actions of IGFs released locally.




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Copyright © 1988 by The Endocrine Society