help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chik, C. L.
Right arrow Articles by Klein, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chik, C. L.
Right arrow Articles by Klein, D. C.

Endocrinology, Vol 122, 1646-1651, Copyright © 1988 by Endocrine Society

ARTICLES

Dual receptor regulation of cyclic nucleotides: alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate

CL Chik, AK Ho and DC Klein
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.

The purpose of this investigation was to determine if alpha 1- adrenergic receptor activation would potentiate the vasoactive intestinal peptide (VIP)-stimulated increase in cAMP accumulation in the rat pinealocyte. Treatment with VIP alone increased cAMP accumulation less than 5-fold, and treatment with phenylephrine increased cAMP accumulation less than 2-fold. However, combined treatment with VIP and phenylephrine increased cAMP accumulation more than 20-fold. This is the first report that alpha 1-adrenergic and VIP receptors can interact to regulate cAMP in a cell of neural tube origin. The demonstration of such an integrated mechanism in pinealocytes is of special interest because VIP innervation of the pineal gland is of central origin, and adrenergic innervation is of peripheral origin. The magnitude of response makes the pinealocyte an attractive model for the study of such dual receptor regulation.


This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
M. Pfeffer, E. Maronde, C. A. Molina, H.-W. Korf, and J. H. Stehle
Inducible Cyclic AMP Early Repressor Protein in Rat Pinealocytes: A Highly Sensitive Natural Reporter for Regulated Gene Transcription
Mol. Pharmacol., August 1, 1999; 56(2): 279 - 289.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society