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Endocrinology, Vol 122, 1455-1459, Copyright © 1988 by Endocrine Society

ARTICLES

Up-regulation of guinea pig myometrial beta-adrenoreceptors by systemic estradiol and progesterone

CG Hatjis, DR Koritnik and A Crews
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

The effects of systemic administration of 17 beta-estradiol (E2) and progesterone (P) on the concentration and affinity of myometrial beta- adrenoreceptors were studied in non-pregnant, previously oophorectomized guinea pigs receiving a continuous infusion of E2, P, a combination of the two hormones, or placebo for 7 days. Myometrial beta- adrenoreceptors were characterized by using (-)-[125I-cyanopindolol as the specific beta-adrenoreceptor ligand. Compared to that in the control group, E2 administration resulted in a 7-fold increase in the density of myometrial beta-adrenoreceptors. Administration of P alone resulted in a significant increase in both beta-adrenergic receptor concentration and the receptor dissociation constant (Kd). Finally, a combination of E2 and P treatment did not result in any synergistic or additive effect for the beta-adrenergic receptors, while the Kd was twice that of the control or E2-treated animals. We conclude that systemic administration of these sex steroid hormones, directly or indirectly, modulates myometrial beta-adrenergic receptor concentrations and their ligand affinity.


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