help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takahashi, N.
Right arrow Articles by Suda, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takahashi, N.
Right arrow Articles by Suda, T.

Endocrinology, Vol 122, 1373-1382, Copyright © 1988 by Endocrine Society

ARTICLES

Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures

N Takahashi, H Yamana, S Yoshiki, GD Roodman, GR Mundy, SJ Jones, A Boyde and T Suda
Department of Biochemistry and Oral Pathology, School of Dentistry, Showa University, Tokyo, Japan.

We developed a mouse bone marrow culture system to examine the process of osteoclast-like multinucleated cell formation from its progenitors. When mouse marrow cells were cultured for 8 days with 1 alpha,25- dihydroxyvitamin D3 [1 alpha,25-(OH)2D3, 10(-10) to 10(-7) M] or human PTH (1-34) (25-100 ng/ml), tartrate-resistant acid phosphatase (TRACP)- positive multinucleated cells formed. No TRACP-positive multinucleated cells appeared in the absence of these hormones. 1 alpha,25-(OH)2D3 and PTH also increased the number of the clusters of TRACP-positive mononuclear cells. Time course studies showed that these TRACP-positive mononuclear cell clusters appeared before the formation of TRACP- positive multinucleated cells, suggesting that the TRACP-positive mononuclear cells are precursors of the multinucleated cells. Salmon calcitonin markedly inhibited the formation of TRACP-positive multinucleated cells but not TRACP-positive mononuclear cell clusters induced by 1 alpha,25-(OH)2D3 or PTH. TRACP-positive mononuclear cells and multinucleated cells were rarely stained for nonspecific esterase, but some mononuclear cells were positively stained for both nonspecific esterase and TRACP. More that 90% of the TRACP-positive mononuclear cell clusters and multinucleated cells were found near colonies of alkaline phosphatase-positive mononuclear cells (possibly osteoblasts). When marrow mononuclear cells were cultured on sperm whale dentine slices in the presence of 1 alpha,25-(OH)2D3 or PTH, numerous resorption lacunae were formed. These results suggest that 1) TRACP- positive multinucleated cells formed in response to osteotropic hormones in mouse marrow cultures satisfy most of the criteria of osteoclasts, and 2) osteoblasts may play an important role in osteoclast formation.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
E. W. Bradley, M. M. Ruan, and M. J. Oursler
Novel Pro-survival Functions of the Kruppel-like Transcription Factor Egr2 in Promotion of Macrophage Colony-stimulating Factor-mediated Osteoclast Survival Downstream of the MEK/ERK Pathway
J. Biol. Chem., March 21, 2008; 283(12): 8055 - 8064.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Yamashita, F. Otsuka, T. Mukai, H. Otani, K. Inagaki, T. Miyoshi, J. Goto, M. Yamamura, and H. Makino
Simvastatin antagonizes tumor necrosis factor-{alpha} inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway
J. Endocrinol., March 1, 2008; 196(3): 601 - 613.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. Gil-Henn, O. Destaing, N. A. Sims, K. Aoki, N. Alles, L. Neff, A. Sanjay, A. Bruzzaniti, P. De Camilli, R. Baron, et al.
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2 / mice
J. Cell Biol., September 7, 2007; 178(6): 1053 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
S. Tsuyoshi Ohnishi, K. Nishino, S. Uchiyama, T. Ohnishi, and M. Yamaguchi
Ki-energy (Life-energy) Stimulates Osteoblastic Cells and Inhibits the Formation of Osteoclast-like Cells in Bone Cell Culture Models
Evid. Based Complement. Altern. Med., June 1, 2007; 4(2): 225 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
K. Nakano, Y. Okada, K. Saito, R. Tanikawa, N. Sawamukai, Y. Sasaguri, T. Kohro, Y. Wada, T. Kodama, and Y. Tanaka
Rheumatoid synovial endothelial cells produce macrophage colony-stimulating factor leading to osteoclastogenesis in rheumatoid arthritis
Rheumatology, April 1, 2007; 46(4): 597 - 603.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
L. Duplomb, M. Dagouassat, P. Jourdon, and D. Heymann
Concise Review: Embryonic Stem Cells: A New Tool to Study Osteoblast and Osteoclast Differentiation
Stem Cells, March 1, 2007; 25(3): 544 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. Kitazawa and S. Kitazawa
Methylation Status of a Single CpG Locus 3 Bases Upstream of TATA-Box of Receptor Activator of Nuclear Factor-{kappa}B Ligand (RANKL) Gene Promoter Modulates Cell- and Tissue-Specific RANKL Expression and Osteoclastogenesis
Mol. Endocrinol., January 1, 2007; 21(1): 148 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
S. Hidaka, Y. Okamoto, S. Uchiyama, A. Nakatsuma, K. Hashimoto, S. T. Ohnishi, and M. Yamaguchi
Royal Jelly Prevents Osteoporosis in Rats: Beneficial Effects in Ovariectomy Model and in Bone Tissue Culture Model
Evid. Based Complement. Altern. Med., September 1, 2006; 3(3): 339 - 348.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Fuller, B. Kirstein, and T. J. Chambers
Murine Osteoclast Formation and Function: Differential Regulation by Humoral Agents
Endocrinology, April 1, 2006; 147(4): 1979 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-T. Woo, M. Kawatani, M. Kato, T. Shinki, T. Yonezawa, N. Kanoh, H. Nakagawa, M. Takami, K. H. Lee, P. H. Stern, et al.
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts
PNAS, March 21, 2006; 103(12): 4729 - 4734.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. C. J. van der Eerden, J. G. J. Hoenderop, T. J. de Vries, T. Schoenmaker, C. J. Buurman, A. G. Uitterlinden, H. A. P. Pols, R. J. M. Bindels, and J. P. T. M. van Leeuwen
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption
PNAS, November 29, 2005; 102(48): 17507 - 17512.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
G A Clines and T A Guise
Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone
Endocr. Relat. Cancer, September 1, 2005; 12(3): 549 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. J. Oursler, E. W. Bradley, S. L. Elfering, and C. Giulivi
Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis
Am J Physiol Cell Physiol, January 1, 2005; 288(1): C156 - C168.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Okamatsu, D. Kim, R. Battaglino, H. Sasaki, U. Spate, and P. Stashenko
MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival.
J. Immunol., August 1, 2004; 173(3): 2084 - 2090.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X. Li, N. Udagawa, M. Takami, N. Sato, Y. Kobayashi, and N. Takahashi
p38 Mitogen-Activated Protein Kinase Is Crucially Involved in Osteoclast Differentiation But Not in Cytokine Production, Phagocytosis, or Dendritic Cell Differentiation of Bone Marrow Macrophages
Endocrinology, November 1, 2003; 144(11): 4999 - 5005.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Zhang, E. Jimi, and A. L. M. Bothwell
Receptor Activator of NF-{kappa}B Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis
J. Immunol., October 1, 2003; 171(7): 3620 - 3626.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Zhang, X. Feng, and J. M. McDonald
The Role of Calmodulin in the Regulation of Osteoclastogenesis
Endocrinology, October 1, 2003; 144(10): 4536 - 4543.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo
Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis
Endocrinology, August 1, 2003; 144(8): 3524 - 3531.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Z. Ke, H. Qi, A. F. Weidema, Q. Zhang, N. Panupinthu, D. T. Crawford, W. A. Grasser, V. M. Paralkar, M. Li, L. P. Audoly, et al.
Deletion of the P2X7 Nucleotide Receptor Reveals Its Regulatory Roles in Bone Formation and Resorption
Mol. Endocrinol., July 1, 2003; 17(7): 1356 - 1367.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Sohara, H. Shimada, M. Scadeng, H. Pollack, S. Yamada, W. Ye, C. P. Reynolds, and Y. A. DeClerck
Lytic Bone Lesions in Human Neuroblastoma Xenograft Involve Osteoclast Recruitment and Are Inhibited by Bisphosphonate
Cancer Res., June 15, 2003; 63(12): 3026 - 3031.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Okada, A. Montero, X. Zhang, T. Sobue, J. Lorenzo, T. Doetschman, J. D. Coffin, and M. M. Hurley
Impaired Osteoclast Formation in Bone Marrow Cultures of Fgf2 Null Mice in Response to Parathyroid Hormone
J. Biol. Chem., May 30, 2003; 278(23): 21258 - 21266.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Bonyadi, S. D. Waldman, D. Liu, J. E. Aubin, M. D. Grynpas, and W. L. Stanford
Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice
PNAS, May 13, 2003; 100(10): 5840 - 5845.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. C. Gowen, D. N. Petersen, A. L. Mansolf, H. Qi, J. L. Stock, G. T. Tkalcevic, H. A. Simmons, D. T. Crawford, K. L. Chidsey-Frink, H. Z. Ke, et al.
Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass
J. Biol. Chem., January 10, 2003; 278(3): 1998 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-K. Lee, J. Kalinowski, S. Jastrzebski, and J. A. Lorenzo
1,25 (OH)2 Vitamin D3-Stimulated Osteoclast Formation in Spleen-Osteoblast Cocultures Is Mediated in Part by Enhanced IL-1{alpha} and Receptor Activator of NF-{kappa}B Ligand Production in Osteoblasts
J. Immunol., September 1, 2002; 169(5): 2374 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Divieti, M. R. John, H. Juppner, and F. R. Bringhurst
Human PTH-(7-84) Inhibits Bone Resorption in Vitro Via Actions Independent of the Type 1 PTH/PTHrP Receptor
Endocrinology, January 1, 2002; 143(1): 171 - 176.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Itoh, N. Udagawa, T. Katagiri, S. Iemura, N. Ueno, H. Yasuda, K. Higashio, J. M. W. Quinn, M. T. Gillespie, T. J. Martin, et al.
Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-{kappa}B Ligand
Endocrinology, August 1, 2001; 142(8): 3656 - 3662.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. V. Reddy, N. Kurihara, C. Menaa, G. Landucci, D. Forthal, B. A. Koop, J. J. Windle, and G. D. Roodman
Osteoclasts Formed by Measles Virus-Infected Osteoclast Precursors from hCD46 Transgenic Mice Express Characteristics of Pagetic Osteoclasts
Endocrinology, July 1, 2001; 142(7): 2898 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Michigami, M. Ihara-Watanabe, M. Yamazaki, and K. Ozono
Receptor Activator of Nuclear Factor {{kappa}}B Ligand (RANKL) Is a Key Molecule of Osteoclast Formation for Bone Metastasis in a Newly Developed Model of Human Neuroblastoma
Cancer Res., February 1, 2001; 61(4): 1637 - 1644.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
L. Xing, A. M. Venegas, A. Chen, L. Garrett-Beal, B. F. Boyce, H. E. Varmus, and P. L. Schwartzberg
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival
Genes & Dev., January 15, 2001; 15(2): 241 - 253.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
S. L. Alatalo, J. M. Halleen, T. A. Hentunen, J. Monkkonen, and H. K. Vaananen
Rapid Screening Method for Osteoclast Differentiation in Vitro That Measures Tartrate-resistant Acid Phosphatase 5b Activity Secreted into the Culture Medium
Clin. Chem., November 1, 2000; 46(11): 1751 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. S. HOLLIDAY, S. L. GLUCK, E. SLATOPOLSKY, and A. J. BROWN
1,25-Dihydroxy-19-nor-vitamin D2, a Vitamin D Analog with Reduced Bone Resorbing Activity In Vitro
J. Am. Soc. Nephrol., October 1, 2000; 11(10): 1857 - 1864.
[Abstract] [Full Text]

Home page
 BloodHome page
T. Michigami, N. Shimizu, P. J. Williams, M. Niewolna, S. L. Dallas, G. R. Mundy, and T. Yoneda
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha 4beta 1-integrin enhances production of osteoclast-stimulating activity
Blood, September 1, 2000; 96(5): 1953 - 1960.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Otsuka, Y. Kato, S. Hirose, and H. Hagiwara
Role of Ascorbic Acid in the Osteoclast Formation: Induction of Osteoclast Differentiation Factor with Formation of the Extracellular Collagen Matrix
Endocrinology, August 1, 2000; 141(8): 3006 - 3011.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X. Li, Y. Okada, C. C. Pilbeam, J. A. Lorenzo, C. R. J. Kennedy, R. M. Breyer, and L. G. Raisz
Knockout of the Murine Prostaglandin EP2 Receptor Impairs Osteoclastogenesis in Vitro
Endocrinology, June 1, 2000; 141(6): 2054 - 2061.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Azuma, K. Kaji, R. Katogi, S. Takeshita, and A. Kudo
Tumor Necrosis Factor-alpha Induces Differentiation of and Bone Resorption by Osteoclasts
J. Biol. Chem., February 18, 2000; 275(7): 4858 - 4864.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Piec, J. Mirkovitch, S. Palacio, P. F. Muhlradt, and R. Felix
Effect of MALP-2, a Lipopeptide from Mycoplasma fermentans, on Bone Resorption In Vitro
Infect. Immun., December 1, 1999; 67(12): 6281 - 6285.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
N. M. PEET, P. S. GRABOWSKI, I. LAKETIC-LJUBOJEVIC, and T. M. SKERRY
The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation
FASEB J, December 1, 1999; 13(15): 2179 - 2185.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
B. S. Lee, S. L. Gluck, and L. S. Holliday
Interaction between Vacuolar H+-ATPase and Microfilaments during Osteoclast Activation
J. Biol. Chem., October 8, 1999; 274(41): 29164 - 29171.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. J. Choi, S. V. Reddy, R. D. Devlin, C. Menaa, H. Chung, B. F. Boyce, and G. D. Roodman
Identification of Human Asparaginyl Endopeptidase (Legumain) as an Inhibitor of Osteoclast Formation and Bone Resorption
J. Biol. Chem., September 24, 1999; 274(39): 27747 - 27753.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-K. Lee and J. A. Lorenzo
Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with Osteoclast-Like Cell Formation
Endocrinology, August 1, 1999; 140(8): 3552 - 3561.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
G. R. Mundy and T. A. Guise
Hormonal Control of Calcium Homeostasis
Clin. Chem., August 1, 1999; 45(8): 1347 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Schmidt, K. Lumniczky, B. D. Tzschaschel, H. L. Guenther, A. Luz, S. Riemann, W. Gimbel, V. Erfle, and R. G. Erben
Onset and Dynamics of Osteosclerosis in Mice Induced by Reilly-Finkel-Biskis (RFB) Murine Leukemia Virus : Increase in Bone Mass Precedes Lymphomagenesis
Am. J. Pathol., August 1, 1999; 155(2): 557 - 570.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. A. Hentunen, S. H. Jackson, H. Chung, S. V. Reddy, J. Lorenzo, S. J. Choi, and G. D. Roodman
Characterization of Immortalized Osteoclast Precursors Developed from Mice Transgenic for Both bcl-XL and Simian Virus 40 Large T Antigen
Endocrinology, July 1, 1999; 140(7): 2954 - 2961.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Matsukawa, W. J. Grzesik, N. Takahashi, K. N. Pandey, S. Pang, M. Yamauchi, and O. Smithies
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
PNAS, June 22, 1999; 96(13): 7403 - 7408.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
T. L. Burgess, Y.-x. Qian, S. Kaufman, B. D. Ring, G. Van, C. Capparelli, M. Kelley, H. Hsu, W. J. Boyle, C. R. Dunstan, et al.
The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts
J. Cell Biol., May 3, 1999; 145(3): 527 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Waki, M. Nomura, S. Kasugai, K. Ohya, and K.-i. Miyamoto
Walker 256/S Carcinosarcoma Causes Osteoporosis-like Changes through Ectopical Secretion of Luteinizing Hormone-releasing Hormone
Cancer Res., March 1, 1999; 59(6): 1219 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Matsuzaki, K. Katayama, Y. Takahashi, I. Nakamura, N. Udagawa, T. Tsurukai, R. Nishinakamura, Y. Toyama, Y. Yabe, M. Hori, et al.
Human Osteoclast-Like Cells Are Formed from Peripheral Blood Mononuclear Cells in a Coculture with SaOS-2 Cells Transfected with the Parathyroid Hormone (PTH)/PTH-Related Protein Receptor Gene
Endocrinology, February 1, 1999; 140(2): 925 - 932.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Rehli, A. Lichanska, A. I. Cassady, M. C. Ostrowski, and D. A. Hume
TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
J. Immunol., February 1, 1999; 162(3): 1559 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Clément-Lacroix, C. Ormandy, L. Lepescheux, P. Ammann, D. Damotte, V. Goffin, B. Bouchard, M. Amling, M. Gaillard-Kelly, N. Binart, et al.
Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice
Endocrinology, January 1, 1999; 140(1): 96 - 105.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Takai, M. Kanematsu, K. Yano, E. Tsuda, K. Higashio, K. Ikeda, K. Watanabe, and Y. Yamada
Transforming Growth Factor-beta Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells
J. Biol. Chem., October 16, 1998; 273(42): 27091 - 27096.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
B. S. Kwon, S. Wang, N. Udagawa, V. Haridas, Z. H. Lee, K. K. Kim, K.-o. Oh, J. Greene, Y. Li, J. Su, et al.
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption
FASEB J, July 1, 1998; 12(10): 845 - 854.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B.-Y. Liu, J. Guo, B. Lanske, P. Divieti, H. M. Kronenberg, and F. R. Bringhurst
Conditionally Immortalized Murine Bone Marrow Stromal Cells Mediate Parathyroid Hormone-Dependent Osteoclastogenesis in Vitro
Endocrinology, April 1, 1998; 139(4): 1952 - 1964.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. A. Kelly, S. Tanaka, R. Baron, and J. M. Gimble
Murine Bone Marrow Stromally Derived BMS2 Adipocytes Support Differentiation and Function of Osteoclast-Like Cells in Vitro
Endocrinology, April 1, 1998; 139(4): 2092 - 2101.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. N. Weilbaecher, C. L. Hershey, C. M. Takemoto, M. A. Horstmann, T. J. Hemesath, A. H. Tashjian Jr., and D. E. Fisher
Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3
J. Exp. Med., March 2, 1998; 187(5): 775 - 785.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Yasuda, N. Shima, N. Nakagawa, S.-I. Mochizuki, K. Yano, N. Fujise, Y. Sato, M. Goto, K. Yamaguchi, M. Kuriyama, et al.
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro
Endocrinology, March 1, 1998; 139(3): 1329 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. A. Guise and G. R. Mundy
Cancer and Bone
Endocr. Rev., February 1, 1998; 19(1): 18 - 54.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
C. Schiller, R. Gruber, K. Redlich, G.-M. Ho, F. Katzgraber, M. Willheim, P. Pietschmann, and M. Peterlik
17{beta}-Estradiol Antagonizes Effects of 1{alpha},25-Dihydroxyvitamin D3 on Interleukin-6 Production and Osteoclast-Like Cell Formation in Mouse Bone Marrow Primary Cultures
Endocrinology, November 1, 1997; 138(11): 4567 - 4571.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. M. Biskobing, D. Fan, X. Fan, and J. Rubin
Induction of Carbonic Anhydrase II Expression in Osteoclast Progenitors Requires Physical Contact with Stromal Cells
Endocrinology, November 1, 1997; 138(11): 4852 - 4857.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
P. L. Schwartzberg, L. Xing, O. Hoffmann, C. A. Lowell, L. Garrett, B. F. Boyce, and H. E. Varmus
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice
Genes & Dev., November 1, 1997; 11(21): 2835 - 2844.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Inoue, P. Santiago, W. C. Horne, and R. Baron
Identification of an Osteoclast Transcription Factor That Binds to the Human T Cell Leukemia Virus Type I-Long Terminal Repeat Enhancer Element
J. Biol. Chem., October 3, 1997; 272(40): 25386 - 25393.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Y. Lee, K. L. Fevold, Y. Muguruma, and J. L. Lottsfeldt
Conditions that Support Long-Term Production of Osteoclast Progenitors In Vitro
Stem Cells, September 1, 1997; 15(5): 340 - 346.
[Abstract] [Full Text]

Home page