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Endocrinology, Vol 120, 2240-2244, Copyright © 1987 by Endocrine Society

ARTICLES

Monoclonal antibodies to a human islet cell surface glycoprotein: 4F2 and LC7-2

S Srikanta, M Telen, JT Posillico, R Dolinar, K Krisch, BF Haynes and GS Eisenbarth

Monoclonal antibodies 4F2 and LC7-2 react with a cell surface differentiation antigen expressed by the endocrine cells of the human pancreatic islet, but not by the acinar pancreatic, ductular, vascular, or stromal connective tissue cells. Western immunoblotting procedures demonstrate the reactivity of the monoclonal antibody 4F2 with a 120 kilodalton islet cell protein in detergent-solubilized cell extracts. These two monoclonal antibodies have potential for application in many aspects of islet cell research and diabetes in general.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1987 by The Endocrine Society