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Endocrinology, Vol 120, 2192-2194, Copyright © 1987 by Endocrine Society

ARTICLES

Decreased insulin responsiveness in fat cells rendered protein kinase C- deficient by a treatment with a phorbol ester

G Cherqui, M Caron, D Wicek, O Lascols, J Capeau and J Picard

Insulin stimulation of 2-deoxyglucose transport and lipogenesis from glucose was examined in fat cells in which protein kinase C had been down-modulated by a 3 h pretreatment with 5 X 10(-7) M 4 beta-phorbol 12 beta-myristate, 13 alpha-acetate (PMA). As compared to control fat cells, the down-modulated cells exhibited a 55-65% decrease in insulin responsiveness with no change in either the hormone sensitivity or the insulin receptor affinity. The present study shows that fat cells made protein kinase C-deficient by chronic treatment with PMA exhibit an insulin-resistant state, distal to the initial step of hormone binding.


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