help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, L. J.
Right arrow Articles by Friesen, H. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, L. J.
Right arrow Articles by Friesen, H. G.

Endocrinology, Vol 120, 1279-1282, Copyright © 1987 by Endocrine Society

ARTICLES

Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat

LJ Murphy, GI Bell and HG Friesen

The insulin-like growth factors (IGFs) have both metabolic and growth- promoting activities in many cell and tissue types. Although the IGFs are present in serum, they are also thought to have important autocrine and paracrine functions. Using complementary DNA (cDNA) probes for rat IGF-I and mouse IGF-II, we have investigated the tissue distribution of messenger RNAs (mRNAs) for these growth factors in adult rats. IGF-I cDNA hybridized with three groups of transcripts, 7.0, 1.8 and 0.7-1.1 kilobases, which were detectable in all tissues examined, with liver demonstrating the highest level of expression. IGF-II cDNA also hybridized to a number of mRNAs, the most abundant of which was 4.0 kilobases. Of the tissues examined, IGF-II expression was highest in the brain, barely detectable in the liver, and undetectable under the conditions used, in lung, ovary, testes, and mammary gland. These studies support the notion of paracrine or autocrine function for IGF-I and demonstrate tissue-specific IGF-II expression in the adult rat.


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
I. Villalpando, E. Lira, G. Medina, E. Garcia-Garcia, and O. Echeverria
Insulin-Like Growth Factor 1 Is Expressed in Mouse Developing Testis and Regulates Somatic Cell Proliferation
Experimental Biology and Medicine, April 1, 2008; 233(4): 419 - 426.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. Kaplan and P. Cohen
REVIEW: The Somatomedin Hypothesis 2007: 50 Years Later
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4529 - 4535.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Zhu and J. W. Pollard
Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling
PNAS, October 2, 2007; 104(40): 15847 - 15851.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
A. K. Kahi and H. Hirooka
Effect of direct and indirect selection criteria for efficiency of gain on profitability of Japanese Black cattle selection strategies
J Anim Sci, October 1, 2007; 85(10): 2401 - 2412.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
W. M. Pardridge
Blood-Brain Barrier Genomics
Stroke, February 1, 2007; 38(2): 686 - 690.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. E. Davis and R. C. M. Simmen
Genetic parameter estimates for serum insulin-like growth factor I concentrations, and body weight and weight gains in Angus beef cattle divergently selected for serum insulin-like growth factor I concentration
J Anim Sci, September 1, 2006; 84(9): 2299 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. S. Daftary and A. C. Gore
IGF-1 in the Brain as a Regulator of Reproductive Neuroendocrine Function
Experimental Biology and Medicine, May 1, 2005; 230(5): 292 - 306.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
V. Chandrashekar, D. Zaczek, and A. Bartke
The Consequences of Altered Somatotropic System on Reproduction
Biol Reprod, July 1, 2004; 71(1): 17 - 27.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Yoshizato, M. Tanaka, N. Nakai, N. Nakao, and K. Nakashima
Growth Hormone (GH)-Stimulated Insulin-Like Growth Factor I Gene Expression Is Mediated by a Tyrosine Phosphorylation Pathway Depending on C-Terminal Region of Human GH Receptor in Human GH Receptor-Expressing Ba/F3 Cells
Endocrinology, January 1, 2004; 145(1): 214 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
T. D. Etherton
Somatotropic function: The somatomedin hypothesis revisited
J Anim Sci, January 1, 2004; 82(13_suppl): E239 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Nakae, Y. Kido, and D. Accili
Distinct and Overlapping Functions of Insulin and IGF-I Receptors
Endocr. Rev., December 1, 2001; 22(6): 818 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. H. Lang, X. Liu, G. J. Nystrom, and R. A. Frost
Acute response of IGF-I and IGF binding proteins induced by thermal injury
Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1087 - E1096.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J.-L. Zhu, C.-I Pao, E. Hunter Jr., K.-w. M. Lin, G.-j. Wu, and L. S. Phillips
Identification of Core Sequences Involved in Metabolism-Dependent Nuclear Protein Binding to the Rat Insulin-Like Growth Factor I Gene
Endocrinology, October 1, 1999; 140(10): 4761 - 4771.
[Abstract] [Full Text]

Home page
 JCBHome page
D. C. Martin, J. L. Fowlkes, B. Babic, and R. Khokha
Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor TIMP-1
J. Cell Biol., August 23, 1999; 146(4): 881 - 892.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Gu, W.S. Branham, D.M. Sheehan, P.J. Webb, C.L. Moland, and R.D. Streck
Tissue-Specific Expression of Messenger Ribonucleic Acids for Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins during Perinatal Development of the Rat Uterus
Biol Reprod, May 1, 1999; 60(5): 1172 - 1182.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
G. A. Surveyor, A. K. Wilson, and D. R. Brigstock
Localization of Connective Tissue Growth Factor during the Period of Embryo Implantation in the Mouse
Biol Reprod, November 1, 1998; 59(5): 1207 - 1213.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Kamegai, T. G. Unterman, L. A. Frohman, and R. D. Kineman
Hypothalamic/Pituitary-Axis of the Spontaneous Dwarf Rat: Autofeedback Regulation of Growth Hormone (GH) Includes Suppression of GH Releasing-Hormone Receptor Messenger Ribonucleic Acid
Endocrinology, August 1, 1998; 139(8): 3554 - 3560.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Rouiller-Fabre, L. Lecerf, C. Gautier, J. M. Saez, and R. Habert
Expression and Effect of Insulin-Like Growth Factor I on Rat Fetal Leydig Cell Function and Differentiation
Endocrinology, June 1, 1998; 139(6): 2926 - 2934.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. D. Walden, W. Ruan, M. Feldman, and D. L. Kleinberg
Evidence That the Mammary Fat Pad Mediates the Action of Growth Hormone in Mammary Gland Development
Endocrinology, February 1, 1998; 139(2): 659 - 662.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Y. Adashi, C. E. Resnick, D. W. Payne, R. G. Rosenfeld, T. Matsumoto, M. K. Hunter, S. E. Gargosky, J. Zhou, and C. A. Bondy
The Mouse Intraovarian Insulin-Like Growth Factor I System: Departures from the Rat Paradigm
Endocrinology, September 1, 1997; 138(9): 3881 - 3890.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. Gnessi, A. Fabbri, and G. Spera
Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment
Endocr. Rev., August 1, 1997; 18(4): 541 - 609.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Escalada, F. Sanchez-Franco, B. Velasco, and L. Cacicedo
Regulation of Growth Hormone (GH) Gene Expression and Secretion During Pregnancy and Lactation in the Rat: Role of Insulin-Like Growth Factor-I, Somatostatin, and GH-Releasing Hormone
Endocrinology, August 1, 1997; 138(8): 3435 - 3443.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-I Pao, K.-w. M. Lin, J.-l. Zhu, G.-j. Wu, P. K. Farmer, and L. S. Phillips
In Vitro Transcription of the Rat Insulin-like Growth Factor-I Gene
J. Biol. Chem., April 12, 1996; 271(15): 8667 - 8674.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
E. Y. Adashi
Insulin-Like Growth Factors as Determinants of Follicular Fate
Reproductive Sciences, November 1, 1995; 2(6): 721 - 726.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
C.-I Pao, J.-l. Zhu, D. G. Robertson, K.-w. M. Lin, P. K. Farmer, S. Begovic, G.-j. Wu, and L. S. Phillips
Transcriptional Regulation of the Rat Insulin-like Growth Factor-I Gene Involves Metabolism-dependent Binding of Nuclear Proteins to a Downstream Region
J. Biol. Chem., October 20, 1995; 270(42): 24917 - 24923.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. P. Kulik, V. M. Kavsan, F. M. A. van Schaik, L. A. Nolten, P. H. Steenbergh, and J. S. Sussenbach
The Promoter of the Salmon Insulin-like Growth Factor I Gene Is Activated by Hepatocyte Nuclear Factor 1
J. Biol. Chem., January 20, 1995; 270(3): 1068 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Roth
Structure of the receptor for insulin-like growth factor II: the puzzle amplified
Science, March 11, 1988; 239(4845): 1269 - 1271.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
J. Billiard, S. S. Grewal, L. Lukaesko, P. J. S. Stork, and P. Rotwein
Hormonal Control of Insulin-like Growth Factor I Gene Transcription in Human Osteoblasts. DUAL ACTIONS OF cAMP-DEPENDENT PROTEIN KINASE ON CCAAT/ENHANCER-BINDING PROTEIN delta
J. Biol. Chem., August 10, 2001; 276(33): 31238 - 31246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1987 by The Endocrine Society