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Endocrinology, Vol 117, 2550-2552, Copyright © 1985 by Endocrine Society

ARTICLES

E-17 alpha-(2-[125I]iodovinyl)-19-nortestosterone: the synthesis of a gamma-emitting ligand for the progesterone receptor

RB Hochberg, RM Hoyte and W Rosner

We have synthesized a gamma-emitting steroid, E-17 alpha-(2- [125I]iodovinyl)-19-nortestosterone (E-IVNT), which is a useful ligand for the sensitive and accurate assay of the progesterone receptor. The synthetic scheme is rapid and is performed with readily available materials. This compound, [125I]E-IVNT, is stable and binds with high affinity to the progesterone receptor.




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Copyright © 1985 by The Endocrine Society