Endocrinology, Vol 117, 2547-2549, Copyright © 1985 by Endocrine Society

ARTICLES

Human growth hormone induces and maintains c-myc gene expression in Nb2 lymphoma cells

WH Fleming, PR Murphy, LJ Murphy, TW Hatton, RJ Matusik and HG Friesen

The effect of human GH (hGH) on c-myc gene expression and cell proliferation in the Nb2 lymphoma cell line was examined. The addition of hormone to stationary cultures of Nb2 cells resulted in an increased accumulation of c-myc transcripts that was detectable within 15 min, reached a maximum induction of 25-fold in 3 h, and then gradually declined. Although maximal accumulation of c-myc transcripts occurred within 3 h after hGH addition, removal of the hormone even after 4 h of treatment resulted in a failure of the cells to proliferate. This loss of proliferative capacity following hormone removal was accompanied by a 20-fold reduction in the level of c-myc transcripts. These results indicate that hGH induced proliferation of Nb2 cells is associated with the induction and maintenance of c-myc gene expression.

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