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Endocrinology, Vol 117, 2249-2251, Copyright © 1985 by Endocrine Society

ARTICLES

TSH and cAMP enhance expression of the myc proto-oncogene in cultured thyroid cells

WH Dere, H Hirayu and B Rapoport

The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAMP and forskolin each enhanced c-myc expression 2.7-fold. These data indicate that TSH, via cAMP as a second messenger, can regulate expression of a cellular oncogene in a non-neoplastic, specific target cell.


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T. Kimura, A. Van Keymeulen, J. Golstein, A. Fusco, J. E. Dumont, and P. P. Roger
Regulation of Thyroid Cell Proliferation by TSH and Other Factors: A Critical Evaluation of in Vitro Models
Endocr. Rev., October 1, 2001; 22(5): 631 - 656.
[Abstract] [Full Text] [PDF]


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