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Endocrinology, Vol 115, 2490-2492, Copyright © 1984 by Endocrine Society

ARTICLES

Insulin-like growth factor I/somatomedin C (IGF-I/Sm C): comparison of natural, solid phase synthetic and recombinant DNA analog peptides in two radioligand assays

D Schalch, D Reismann, C Emler, R Humbel, CH Li, M Peters and E Lau

Investigation of the biologic activity of Insulin-like Growth Factor I/Somatomedin C (IGF-I/Sm C) has been hampered by the scarcity of purified material. The synthesis of this molecule by the solid phase procedure and an analog of IGF-I/Sm C by recombinant DNA technology offers promise that studies of the biologic activity of IGF-I/Sm C will soon be possible. We have found that natural IGF-I/Sm C and the two synthetic peptides behave similarly in two radioligand systems, providing evidence that these molecules possess the requisite structural integrity for use in such biological studies.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society