help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Riskind, P. N.
Right arrow Articles by Martin, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Riskind, P. N.
Right arrow Articles by Martin, J. B.

Endocrinology, Vol 114, 1232-1237, Copyright © 1984 by Endocrine Society

ARTICLES

Opiate modulation of the anterior pituitary hormone response during suckling in the rat

PN Riskind, WJ Millard and JB Martin

We have investigated the influence of endogenous opiates on hormone responses during suckling in the rat. In complementary experiments, opiate receptors were blocked by naloxone (NAL) or endogenous opiate release from the pituitary was inhibited by dexamethasone (DEX). Serial blood samples from unanesthetized suckled rats were then assayed for plasma PRL, beta-endorphin-like immunoreactivity (beta-END-LI), TSH, and GH levels. Identical studies were also done in saline-treated (control) suckled rats and in unsuckled rats exposed to control objects. Whereas suckling caused a rise in plasma PRL, beta-END-LI, and GH, introduction of plastic control objects did not elevate hormone levels. NAL blocked the GH rise and depressed TSH levels, but did not significantly inhibit the PRL or beta-END-LI response. DEX prevented the beta-END-LI rise and blocked the GH rise, but did not inhibit TSH. DEX enhanced PRL release during suckling. These results demonstrate that 1) the responses of beta-END-LI, PRL, and GH are not an artifact of the sampling procedure; 2) PRL release during suckling is independent of beta-END-LI release by the pituitary; and 3) suckling stimulates the release of ACTH, beta-END, and beta-lipotropin from the anterior pituitary. Our results are consistent with both a role of pituitary beta-END in the control of GH and a role of corticosterone in the control of PRL during suckling.


This article has been cited by other articles:


Home page
 J EndocrinolHome page
T. Misztal, K. Gorski, D. Tomaszewska-Zaremba, E. Molik, and K. Romanowicz
Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release
J. Endocrinol., July 1, 2008; 198(1): 83 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Aurich, T. Gerlach, J. E. Aurich, and N. Parvizi
Seasonal Variation and Opioidergic Regulation of Growth Hormone Release in Cyclic, Ovariectomized, and Pregnant Pony Mares
Biol Reprod, December 1, 1999; 61(6): 1575 - 1580.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Escalada, F. Sanchez-Franco, B. Velasco, and L. Cacicedo
Regulation of Growth Hormone (GH) Gene Expression and Secretion During Pregnancy and Lactation in the Rat: Role of Insulin-Like Growth Factor-I, Somatostatin, and GH-Releasing Hormone
Endocrinology, August 1, 1997; 138(8): 3435 - 3443.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society