help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seino, Y.
Right arrow Articles by Avioli, L. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seino, Y.
Right arrow Articles by Avioli, L. V.

Endocrinology, Vol 113, 1721-1725, Copyright © 1983 by Endocrine Society

ARTICLES

The duodenal 1 alpha,25-dihydroxyvitamin D3 receptor in rats with experimentally induced diabetes

Y Seino, RI Sierra, YM Sonn, A Jafari, SJ Birge and LV Avioli

Studies in the rat with streptozotocin-induced diabetes of short and long duration revealed decreased circulating 1 alpha,25- dihydroxyvitamin D [1,25-(OH)2D] levels and an intact 1,25-(OH)2D3 duodenal cytosolic receptor with a sedimentation coefficient of 3.3S. Whereas no significant alterations in the equilibrium dissociation constant (Kd) were observed in the diabetic animals, the number of 1,25- (OH)2D3-binding sites was increased in the animals with short term (235 +/- 48 vs. 100 +/- 15 fmol/mg protein) and long term (521 +/- 60 vs. 119 +/- 15 fmol/mg protein) diabetes. The data are consistent with the hypothesis that alterations in intestinal calcium absorption previously observed in the diabetic state are due, at least in part, to dynamic relationships between circulating 1,25-(OH)2D concentrations and the number of intestinal 1,25(OH)2D3-binding sites.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society