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Endocrinology, Vol 112, 384-386, Copyright © 1983 by Endocrine Society

ARTICLES

Regulation of rat adipocyte glucose transport by growth hormone: no mediation by insulin-like growth factors

E Schoenle, J Zapf and ER Froesch

Growth hormone (GH) in vivo is responsible for normal glucose transport in isolated rat fat cells: In fat cells of hypophysectomized (hypox) rats basal glucose transport is maximal and insulin-insensitive. GH treatment of hypox rats restores the basal glucose transport rate towards normal and renders it again insulin-sensitive. The aim of this study was to find out whether these are direct effects of GH or effects that are mediated by GH-dependent insulin-like growth factors (IGF) I or II. Whereas IGF I and II infused into hypox rats stimulate growth, they do not normalize the glucose transport system in fat cells. Thus, the restriction of basal glucose transport in adipocytes seems to be directly controlled by GH.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1983 by The Endocrine Society