help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fradkin, J. E.
Right arrow Articles by Wolff, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fradkin, J. E.
Right arrow Articles by Wolff, J.

Endocrinology, Vol 110, 2018-2023, Copyright © 1982 by Endocrine Society

ARTICLES

Adenosine receptor-mediated accumulation of adenosine 3',5'- monophosphate in guinea pig thyroid tissue

JE Fradkin, W Hardy and J Wolff

The cAMP content of guinea pig thyroid fragments was increased 2- to 3- fold by adenosine analogs, 5'-N-ethylcarboxamide adenosine (NECA), the most potent, caused half-maximal stimulation of 0.7 microM, whereas N6- phenylisopropyl adenosine was much less potent (half-maximal stimulation at 20 microM). Exogenous adenosine by itself was slightly active, and its activity was increased in the presence of adenosine deaminase or transport inhibitors. Although adenosine analogs are partial agonists compared to TSH or the diterpene cyclase activator forskolin, the fractional rate of cAMP accumulation is greater for NECA than for TSH. The stimulatory effect of NECA was antagonized by theophylline. These effects of adenosine and its analogs on cAMP formation in intact thyroid tissue are characteristic of stimulatory adenosine receptors.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1982 by The Endocrine Society