help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crandall, E. A.
Right arrow Articles by Fernstrom, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crandall, E. A.
Right arrow Articles by Fernstrom, J. D.

Endocrinology, Vol 109, 310-312, Copyright © 1981 by Endocrine Society

ARTICLES

Reduction in brain serotonin synthesis rate in streptozotocin-diabetic rats

EA Crandall, MA Gillis and JD Fernstrom

The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.


This article has been cited by other articles:


Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
B. Sabayan, F. Foroughinia, A. Mowla, and A. Borhanihaghighi
Role of Insulin Metabolism Disturbances in the Development of Alzheimer Disease: Mini Review
American Journal of Alzheimer's Disease and Other Dementias, May 1, 2008; 23(2): 192 - 199.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
J. D. Fernstrom
Branched-Chain Amino Acids and Brain Function
J. Nutr., June 1, 2005; 135(6): 1539S - 1546S.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
N. Rasgon and L. Jarvik
Insulin Resistance, Affective Disorders, and Alzheimer's Disease: Review and Hypothesis
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2004; 59(2): M178 - 183.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society