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Endocrinology, Vol 103, 548-553, Copyright © 1978 by Endocrine Society

ARTICLES

Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer

WG Blackard, PS Guzelian and ME Small

Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.


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J. Caro and J. Amatruda
Insulin receptors in hepatocytes: postreceptor events mediate down regulation
Science, November 28, 1980; 210(4473): 1029 - 1031.
[Abstract] [PDF]

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R. Misbin, J. O'Leary, and A Pulkkinen
Insulin receptor binding in obesity: a reassessment
Science, September 7, 1979; 205(4410): 1003 - 1004.
[Abstract] [PDF]


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