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Endocrinology, Vol 102, 984-987, Copyright © 1978 by Endocrine Society

ARTICLES

Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen

DW Schomberg, RF Williams, L Tyrey and LC Ulberg

Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.


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P L Rangel, P J Sharp, and C G Gutierrez
Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens.
Reproduction, June 1, 2006; 131(6): 1109 - 1114.
[Abstract] [Full Text] [PDF]


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Copyright © 1978 by The Endocrine Society