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Endocrinology, Vol 101, 1894-1897, Copyright © 1977 by Endocrine Society

ARTICLES

Increase in dopamine content of the rat median eminence after long-term ovariectomy and its reversal by estrogen replacement

GA Gudelsky, L Annunziato and KE Moore

The norepinephrine (NE) and dopamine (DA) concentrations of the median eminence and the remaining hypothalamus of female rats were assayed using a sensitive radioenzymatic method. There were no changes in the catecholamine concentrations of either brain region when measured in the mornings of the different days of the estrous cycle. Four to 5 weeks after ovariectomy there was a marked increase in the DA but not the NE content of the median eminence, and the daily administration of estradiol benzoate for 7 days prior to sacrifice reversed the ovariectomy-induced increase in DA. Ovariectomy did not alter catecholamine concentrations in the remaining hypothalamus.


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M. Blank, A. Panerai, and H. Friesen
Opioid peptides modulate luteinizing hormone secretion during sexual maturation
Science, March 16, 1979; 203(4385): 1129 - 1131.
[Abstract] [PDF]


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Copyright © 1977 by The Endocrine Society