Endocrinology, Vol 101, 1939-1942, Copyright © 1977 by Endocrine Society
Suppression of serum follicle stimulating hormone in intact and acutely ovariecomized rats by porcine follicular fluid
ML Marder, CP Channing and NB Schwartz
Sham ovariectomy (SOV) or ovariectomy (OVX) was performed at 0800h of
metastrus; porcine serum (PS) or porcine follicular fluid (PFF) was
injected intraperitoneally at 0830h and/or 1130h, with terminal blood
samples collected at 1700h. Fluid from medium and large follicles in
porcine ovaries, charcoal extracted to remove steroids, significantly
reduced serum FSH, in a dose-dependent manner. Futhermore, the SOV rats
were more sensitive to PFF with respect to serum FSH lowering than the OVX
rats, although when enough PFF was injected, both groups showed the same
level of suppression. Since serum LH was very low, the possible effect of
PFF on this hormone could not be assessed.
